A0A7J7EB44 · A0A7J7EB44_DICBM

Function

function

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionvery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity
Biological Processfatty acid elongation
Biological Processsphingolipid biosynthetic process
Biological Processvery long-chain fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
  • EC number

Gene names

    • ORF names
      HPG69_007804

Organism names

Accessions

  • Primary accession
    A0A7J7EB44

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-29Helical
Transmembrane49-72Helical
Transmembrane124-142Helical
Transmembrane186-206Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the very long-chain fatty acids dehydratase HACD family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    227
  • Mass (Da)
    27,058
  • Last updated
    2021-04-07 v1
  • Checksum
    68ACAB85B1F0F14B
MVFSCIYRYRKNAYLFIYYLIQFCGHSWILTNMTVRFFSFGKDSMVDTFYAIGLVMRLCQSISLLELLHICVGIESNHLLPRFLQLTERIIILFVVITSQEEVQEKYVVCVLFFFWNLLDMVRYTYSMLSVIGISYAVLTWLSQTLWMPIYPLCVLAEAFAVYQSLPYFESFGTYSTKLPFDLSIYFPYVLKIYLMMLFIGMYFTYSHLYSERSDILRVFPIKKKKM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010003801
EMBL· GenBank· DDBJ
KAF5912814.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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