A0A7J7EB44 · A0A7J7EB44_DICBM
- ProteinVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids227 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalytic activity
- (3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2OThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity | |
Biological Process | fatty acid elongation | |
Biological Process | sphingolipid biosynthetic process | |
Biological Process | very long-chain fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVery-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7EB44
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-29 | Helical | ||||
Sequence: NAYLFIYYLIQFCGHSWI | ||||||
Transmembrane | 49-72 | Helical | ||||
Sequence: FYAIGLVMRLCQSISLLELLHICV | ||||||
Transmembrane | 124-142 | Helical | ||||
Sequence: YTYSMLSVIGISYAVLTWL | ||||||
Transmembrane | 186-206 | Helical | ||||
Sequence: YFPYVLKIYLMMLFIGMYFTY |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the very long-chain fatty acids dehydratase HACD family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length227
- Mass (Da)27,058
- Last updated2021-04-07 v1
- Checksum68ACAB85B1F0F14B
Keywords
- Technical term