A0A7J7E8I1 · A0A7J7E8I1_DICBM

Function

function

The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular region
Cellular Componentgrowth hormone receptor complex
Molecular Functioncytokine binding
Molecular Functiongrowth factor binding
Molecular Functiongrowth hormone receptor activity
Molecular Functionpeptide hormone binding
Biological Processendocytosis
Biological Processgrowth hormone receptor signaling pathway
Biological Processpositive regulation of peptidyl-tyrosine phosphorylation
Biological Processpositive regulation of receptor signaling pathway via JAK-STAT

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Growth hormone receptor
  • Alternative names
    • Somatotropin receptor

Gene names

    • ORF names
      HPG69_003379

Organism names

Accessions

  • Primary accession
    A0A7J7E8I1

Proteomes

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane262-284Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_502975412322-635Growth hormone receptor

Keywords

Interaction

Subunit

On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain148-251Fibronectin type-III
Region419-474Disordered
Compositional bias424-447Polar residues
Region568-590Disordered

Sequence similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    635
  • Mass (Da)
    70,956
  • Last updated
    2021-04-07 v1
  • Checksum
    F2CE173E04DCC6D1
MYMRPYITLLISCLAFSFYSADSSGKPKFTKCRSPELETFSCHWTDGGRHGFKHPGSVQLFYIRRSTQEWTQEWKECPDYVSAGENSCYFNSSYTSIWIPYCIKLTSNGGTVDQKCFSVEEIESTLLISSCVSLCTNSLLKCTVQPDPPIGLNWTLLNISLTGIHADIQVRWEPPPNADVQKGWIVLEYELQYKEVNETQWKMMDPVLSTSVPVYSLRLDKEYEVRVRSRQRNSEKYGEFSEVLCVTLPQMSPLACEEDVRFPWFLIIILGIFGLTVILFLFIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDNYKPEFYNDDSWVEFIELDIDDPDEKTEGSDTDRLLSNDHQKSLNILGAKDDDSGRTSCYEPDILETDFNASDMCNGTSEVAQPQRLKGEADLLCLDQKNQNDSPTSNATPATQQPSVILAEENKPRPLPIGGTESTHPAAHTQLSNPSSLANIDFYAQVSDITPAGXXXLSPGQKNKAGISQCDMHPEAVSLCQANFIMDNTYFCEADAKKCIAGAPHVEVESRVEPSFNQEDIYITAESLTTTAGRSGTAEHPSSSEMPVPDYTSIHIVQSPQGLVLNATALPLPDKEFLSSCGYVSTDQLNKIMP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias424-447Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010003868
EMBL· GenBank· DDBJ
KAF5912105.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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