A0A7J7E7E8 · A0A7J7E7E8_DICBM
- ProteinTransporter
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids623 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- serotonin(out) + K+(in) + Na+(out) + H+(in) = serotonin(in) + K+(out) + Na+(in) + H+(out)This reaction proceeds in the forward direction.serotonin (out)CHEBI:350546
+ K+ (in)CHEBI:29103+ Na+ (out)CHEBI:29101+ H+ (in)CHEBI:15378= serotonin (in)CHEBI:350546+ K+ (out)CHEBI:29103+ Na+ (in)CHEBI:29101+ H+ (out)CHEBI:15378
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 94 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 96 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 97 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 101 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 336 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 368 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 434 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 437 | Na+ 1 (UniProtKB | ChEBI) | |||
Binding site | 438 | Na+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endosome membrane | |
Cellular Component | focal adhesion | |
Cellular Component | neuron projection | |
Cellular Component | plasma membrane | |
Cellular Component | presynapse | |
Molecular Function | antiporter activity | |
Molecular Function | metal ion binding | |
Molecular Function | serotonin binding | |
Molecular Function | serotonin:sodium:chloride symporter activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTransporter
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7E7E8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Endosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 88-106 | Helical | |||
Transmembrane | 118-139 | Helical | |||
Transmembrane | 160-188 | Helical | |||
Transmembrane | 251-268 | Helical | |||
Transmembrane | 280-306 | Helical | |||
Transmembrane | 326-350 | Helical | |||
Transmembrane | 362-387 | Helical | |||
Transmembrane | 422-443 | Helical | |||
Transmembrane | 464-489 | Helical | |||
Transmembrane | 495-516 | Helical | |||
Transmembrane | 536-558 | Helical | |||
Transmembrane | 570-588 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 200↔209 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-62 | Disordered | |||
Domain | 24-64 | Sodium:neurotransmitter symporter serotonin N-terminal | |||
Compositional bias | 41-62 | Polar residues | |||
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length623
- Mass (Da)69,496
- Last updated2021-04-07 v1
- MD5 Checksum91355A9F330D3A7C9406CCA7F388BF72
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 41-62 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACDTQ010003894 EMBL· GenBank· DDBJ | KAF5911668.1 EMBL· GenBank· DDBJ | Genomic DNA |