A0A7J7CA51 · A0A7J7CA51_TRIWF

Function

function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Allosterically activated by AMP.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.

Features

Showing features for binding site, site, active site.

TypeIDPosition(s)Description
Binding site146ATP (UniProtKB | ChEBI)
Binding site209-210ATP (UniProtKB | ChEBI)
Binding site234-237ATP (UniProtKB | ChEBI)
Binding site235Mg2+ (UniProtKB | ChEBI); catalytic
Site236Important for substrate specificity; cannot use PPi as phosphoryl donor
Binding site263-265substrate
Active site265Proton acceptor
Binding site308-310substrate
Binding site364substrate
Binding site421-424substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function6-phosphofructokinase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processfructose 6-phosphate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent 6-phosphofructokinase
  • EC number
  • Short names
    ATP-PFK
    ; Phosphofructokinase
  • Alternative names
    • Phosphohexokinase

Gene names

    • Name
      PFK
    • ORF names
      HS088_TW19G00647

Organism names

  • Taxonomic identifier
  • Strain
    • cv. XIE 37
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Celastrales > Celastraceae > Tripterygium

Accessions

  • Primary accession
    A0A7J7CA51

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain140-445Phosphofructokinase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    519
  • Mass (Da)
    57,530
  • Last updated
    2021-04-07 v1
  • Checksum
    89E8AEF5EF82750A
MDLSVHTASPSLPFPHHSSLLFNSCSHSMLRLEYRSLYWKPLSWRQNRAIRAQSPNQTPNDGFVLDDVPHLTHFLPDLPSYPNPLQNSQAYAIVKQTFVSPEDVVAQRIVVQKDTPRGVHFHRAGPREKVYFKPEEVCACIVTCGGLCPGINTVIREIVCGLNYMYGVDDILGIQGGYRGFYSKNTMRLTPKVVNDIHKRGGTFLQTSRGGHDTHKIVDNIQDRGINQVYIIGGDGTQKGAALIYEEVEKRGIQVAVAGIPKTIDNDIAVIDKSFGFDTAVEEAQRAINAAHVEVESVENGVGVVKLMGRYSGFIAMHATLASRDVDCCLIPESPFYLEGQGGLFEFIEKRLKENGHVVIVLAEGAGQGYVAQSMHAADERDASGNRLLLDVGLWLSQKIKDHFTKVQKMAVNMKYIDPTYMIRAIPSNASDNIYCTLLAHSAVHGAMAGYTGFTVGPVNCKHAYIPIARVTERTNTVKLTDRMWARLLASTNQPTFLNCNEKLQEVDEEINNFKIPSI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAARO010000019
EMBL· GenBank· DDBJ
KAF5731044.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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