A0A7J6R2Y5 · A0A7J6R2Y5_PEROL

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

methylcob(III)alamin (UniProtKB | Rhea| CHEBI:28115 )

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.

Features

Showing features for binding site.

148450100150200250300350400450
TypeIDPosition(s)Description
Binding site258Zn2+ (UniProtKB | ChEBI)
Binding site321Zn2+ (UniProtKB | ChEBI)
Binding site322Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalamin binding
Molecular Functionmetal ion binding
Molecular Functionmethionine synthase activity
Biological Processhomocysteine metabolic process
Biological Processmethylation
Biological Processtetrahydrofolate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    methionine synthase
  • EC number
  • Alternative names
    • 5-methyltetrahydrofolate--homocysteine methyltransferase
    • Vitamin-B12 dependent methionine synthase

Gene names

    • ORF names
      FOZ63_001965

Organism names

Accessions

  • Primary accession
    A0A7J6R2Y5

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-336Hcy-binding
Domain368-484Pterin-binding

Sequence similarities

Belongs to the vitamin-B12 dependent methionine synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    484
  • Mass (Da)
    53,553
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    4473CD7F9F505BA6ADD16A709DE6EC10
MLAWPQHPGGESESTGYLRKLFAERIVFLDGGMGTRIQAERLQEEDFRGEILKDHPKELKGDNDLLCLTRPDLVVKIHKEYLHAGADLIETNTFNGTTISQAEYQCESLVRDLNYQAAKLAKQACQEVEAETGQRRLVAGAIGPTSRTLSVSPSVEDSSYRNVTWNELVKSYYEQVEALIAGGSDVLLVETIFDTLNAKAALFAIDGYYEDHSQEPRLPTIISATIVDQSGRTLSGQTIDAFLVSVMHARPLCVGINCALGASQMRPFFETLAKLAPVYVHVYPNAGLPNAMGGYDETPESFGESLVLYAQDHLLNMVGGCCGTFPAHIEAVHERLKGFPPRPLHVRQDSVMRLSGLEPLYLTPELGFVNVGERCNLMGSLRFKKMVEQSRWDDALEVAKEQVENGAQVLDFNFDADLIDGQLAMGRFMRSCVTEPAIARVPFMIDSSKFKVIEEGLQAVQGRCIVNSLSLKVGEEDFIFHAKL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue484

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABANO010028356
EMBL· GenBank· DDBJ
KAF4715279.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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