A0A7J6M9F3 · A0A7J6M9F3_PEROL

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site2367-2371(6S)-NADPHX (UniProtKB | ChEBI)
Binding site2368K+ (UniProtKB | ChEBI)
Binding site2437K+ (UniProtKB | ChEBI)
Binding site2441-2447(6S)-NADPHX (UniProtKB | ChEBI)
Binding site2472(6S)-NADPHX (UniProtKB | ChEBI)
Binding site2475K+ (UniProtKB | ChEBI)
Binding site2641(6S)-NADPHX (UniProtKB | ChEBI)
Binding site2707-2713(6S)-NADPHX (UniProtKB | ChEBI)
Binding site2747-2751ATP (UniProtKB | ChEBI)
Binding site2767-2776ATP (UniProtKB | ChEBI)
Binding site2777(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular FunctionATP-dependent NAD(P)H-hydrate dehydratase activity
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processnicotinamide nucleotide metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multifunctional fusion protein

Including 2 domains:

  • Recommended name
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ATP-dependent NAD(P)HX dehydratase
  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • ORF names
      FOL46_002136

Organism names

Accessions

  • Primary accession
    A0A7J6M9F3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1605-1631Helical
Transmembrane1652-1672Helical
Transmembrane1678-1695Helical
Transmembrane1716-1737Helical
Transmembrane1769-1786Helical
Transmembrane1798-1815Helical
Transmembrane1900-1924Helical
Transmembrane2123-2143Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for coiled coil, compositional bias, region, domain.

TypeIDPosition(s)Description
Coiled coil110-171
Compositional bias228-248Basic and acidic residues
Region228-252Disordered
Compositional bias430-455Polar residues
Region430-456Disordered
Region2230-2249Disordered
Domain2314-2530YjeF N-terminal
Domain2534-2841YjeF C-terminal
Compositional bias2882-2896Polar residues
Region2882-2903Disordered
Region3158-3231Disordered
Compositional bias3166-3184Basic residues
Region3249-3301Disordered
Compositional bias3262-3285Polar residues

Sequence similarities

Belongs to the NnrD/CARKD family.
Belongs to the NnrE/AIBP family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,386
  • Mass (Da)
    370,119
  • Last updated
    2021-04-07 v1
  • Checksum
    D6BE7B89B3305CAA
MGLRSALAVPAAALSAVWLLISVCAVLYIVVAPVERGARENLADLKLEYATKRAALAKEISELEAGLKQDGASMSRDQRSTQFQLQQAKSSLRSVEGRIRSAHDDYIRRNEEHSRLKEGMESEIRKLKNTLATGDPETSTSTELSACLTHIAEASYAYNKLEDQLADLKTLRPFSFNSVVTTPDLLAVYVSSSTEKTMTSRLMVEQLVSSLLATQRDSTSPLTIRVETDEEHKNPWKRPVEECGRGGGGSRDRSFVTMSPNTVVFDGWLRDILKCISSTNQRGHPIAVCCMMVITPTGEHECDEGFFAARCDSAVLEGISSIPADRASARSAFNSVMGRLGDRVRYLPLSEYRRQHIGDGGGDVTTFDVRTLLKVYRASGDGSKVLDRLLRMRARALEEKFNEVESDTRNRAMVRATMGGACEITLSATHAAKRESSAPSDNGQSQWTALRSPGDSAASATADRCHEVIGLIPSYGKDVEDELTLWLNQRYYSDPLPYDHPVKIRSEWIPAIPSLPQSSKALRDAPVMGIAGDQQLLAQRHSSLLEHPSLKSLLLPGSAIDPFLGFVKAAVMRTPSESEAINEMRQRIRDDLVASGRLPFGKDEDLAKRDLESVDRAVELEKMYREQQKEQNCDREDGNMTAGQLLQLLLATSVRLTAPQDTSEISEEVVWRLRKTDDTQLQWFVRELRWFGDPDCAGEELEPIPENETVTGSNVVASHNFYDAPLTRDGDLSTGWRASTCAISCFIGYQFPPSVSVRCLKLLQGADKSELAYSARLERKLQDDATYTRILDFDFLSGDTWMRLNEVWVFPPSRRRWRIANVEAVRGPWTIVDLAFYVDSSCEVDATLSVNATPMSSPFKATNGPTAIRNPSTEWTAECVTAECGRNEAWIGLQFEAEMPLIECVKMQQQAGDDTYVSSVVLQYLSGETEWSTMARYDGLFGGTRLVLSPMLPQSSWRLTAAQTMNRQWDIRELELYGDAECTEALHPVQHDGGYSLAARLDQGLVRDIAIIASSHGGSRRPTYAFDGVTDDPTKSWRSRCSSCYEGEAYIGLRWISATPPVVACVRAFFSPQYSVGRAAIEYIGTVRWETAYSFDLLSGGSWLSLTYGGQMPFPGVLRVYPNYNSTIWRLRSRGWGLIACGSDLTEGCPVWRVEMYANPECRGDPVQGQPVSSPGVAGEREDPYLVHDGRDETGWLASLPYYDDYAGSYEDEIRGTAPTPRPFDDKSQVPWIGLVTDSTIRCVRVYESTKAGALFPEAAHEGDLMNEIVLERLLAWRSAIQWEATMNLRYRAFDLNPDTFWQPAADDYNPWIGIMFTAVDGANSSREVKCVRILQPAEVKNVAMSVVLETSEPNNQGWLQVRVFHFLSGGMWSGLTETAAKPPQNTRWRIVNTAPLGKRLLWKVYDIRLYNSEQCTDQSRIPTTSAFGVTAIASGYTADNPPQYAFDADGLTTAWWAPCDYCGENPFVAPMCQEARAEAVSLTAYNGLLFYRRVFLFDPDRLPAGGIDIQCVTIGANALVEELLWALQVYDPVSEACLENPGARECWRNDAYRLAIKFEYRPQVDVTRQTCSPGASDTTDPDCATEVVYVTTPMPESRDNPLEMLVLVISAILSPIATAIALLSCCHTMLMVPDEDKREMSELTQWKTARITIALVAGLFYAIVHAAWLLITLLVSGLILVAVFAVGLVASIRMERWASTDYHLYRTSLPQSRDFWFQSLLMLALFTLINIVSSLFDLACVRYVLTILGLCLFGHDGCREPIPLVPTYLYSTIPGSLGGWLLAALRGSSYKCAGTSLIVSSIMTTTTGAMLWAITTLDILGLVECARYAALVHRKWLTWTKLSLTKGVLTASCQVLCLASVTSLKLLLDPTEQLFHETSGCDQVDHRHEDPPIASHAPFMTWVFGQSLAWVAVCFVLLTGVALNVTGQHFAAGLDEHLEGILKMEGLGTLEQGVMDADSDTGSVYFRDYEEARERGIRDYGALLLGCWWRCKYRMRGWLSFGWVCIGRWTHTARGRGFQVASRADYYSRVFLPLFQQPPQPTMAVPSTPTSPYSPSALAAVRDVLDDVDVSKLDGVEGGDVDTVRSLLGKVHSLGRAMKICSQARGGLIIFIAFFSGPDIRVLFPVTGLVILLVLCLMESLLQGVHLVIYSYELSYQVIAEQLHVGSDVHDGETLFEEEAQDEEELRFQQTRSKLAKTLTNLFSRGKSHGGEGVEMARRNPSRVAATPLGLRHEGSGESTGTSVKRGVKKRTAKGSAHVIAVFPLWWSTACVDPRVLLLAMNTCCLLSAITSAVVKGAVAAAPPMKVSTCDQMRRCDKNATDKYSIPSALLMENAGITSYRCLTELLPNSRMTPQTKVLVVCGPGNNGGDGFVVARYVHSNGGQVRVILLNSREKYHGDASTNLNIVDCIPGIPVEIATTEEAISAAVDWADVLVDGIFGTGLGRVVDPSSPFGMAIAAVNRAKKPVMSLDIPSGVNGDSGRIMGDQAVHATATATFGLVKVGNLVYPGREMCGNLTVTHIGYPPELYADLDTYVNYFPPLPARSPAGHKGSFGKALFVAGAEGYYGAPMLSSYSFLKAGGGYSRLATVKSIIPVIAAEAPSIVFHELESTSAGSISSDNYDRVFKMAQHLADMVVVGPGVSTNGDTARLVRALVLSSEKPMVIDGDGLTAISAAPVDSTDIFSTASQLLQERHRKQLPPVVLTPHLAELSRLTGISMGELTDGSRSLLEVGRELAQKTNAVVVVKGATSMICEPSGRVRMNLSGNSGMGTAGSGDVLSGLIPAMYAAYGHEVDSLGDAVAAAVFLHGVAGDIAAINLRGEDGVTASDIMNAVPEAVSYVRGESAFGKYSSELESRYSIFLAKRRLVLSMGGTASPGSWCLSMSSSSSASSRPTERPLQMPFPDIRDSVDGVEQPRDQPPPPIAAIVPVAEEALPVTTEPPPSLVAVEKRIKEVTEEIARLEKEGSLSSEIPEEYLAMTKVEITKPPKMKSLSESDLQIPRAKKAQPDEKVLARKALLSRIEKEVGEEIERQREEEIKRGIDLRARFASRSKVWDIQVPRAVRDEHWIEPGPEVCRHALLGVLSGVISVTTAALPGRGGDPSGGAVYATVVTKRDLTEGYKKSLVRALSPYGIQAIVLSVESLRSLVLSQGAAVEVDQASQGRGVAKHRKKGKRGKRGRKGGSAKPSRSVPVPKIVAGPTTSPRVAASEVLRKPQEGAPEEENAEENIPVAANEAEAPTEHVASGELEMKENAESPRVECPSPSKETSSRCDHFCISTPNDSEATGPGMEHGLDEEEHDDDDIENEDDYIADAVGTWLGVDDLDEDHNRDDSEYLDQHGSPRARNAAATMTFFNTAATAFGFSKAMGMHQKFAGVVDIVEDSGLL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias228-248Basic and acidic residues
Compositional bias430-455Polar residues
Compositional bias2882-2896Polar residues
Compositional bias3166-3184Basic residues
Compositional bias3262-3285Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JABANN010000167
EMBL· GenBank· DDBJ
KAF4668149.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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