A0A7J6KD88 · BPK1_TOXGO
- ProteinBradyzoite pseudokinase 1
- GeneBPK1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids377 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Required for the growth, maintenance, and/or stability, and thus infectivity, of bradyzoite cysts.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cyst wall | |
Cellular Component | extracellular space | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Biological Process | protein phosphorylation |
Names & Taxonomy
Protein names
- Recommended nameBradyzoite pseudokinase 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma
Accessions
- Primary accessionA0A7J6KD88
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: During the bradyzoite stage, secreted into the cyst lumen and localizes to the cyst wall.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
In a mouse infection model, tachyzoite growth, conversion to bradyzoites and cyst formation are normal 4 weeks post-infection (PubMed:23291621).
However, cysts are smaller and their capacity to cause oral infection in a mouse host is reduced which is probably due to their increased susceptibility to the conditions in the host digestive system (PubMed:23291621).
However, cysts are smaller and their capacity to cause oral infection in a mouse host is reduced which is probably due to their increased susceptibility to the conditions in the host digestive system (PubMed:23291621).
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MANTSVRRRQLLSSVLLLQWLTTVLG | ||||||
Chain | PRO_5029621146 | 27-377 | Bradyzoite pseudokinase 1 | |||
Sequence: VAWGPNPIDGSKHGQFPSLRRTEGVSQSGSGHKGSVYRIPLADMTFWSWMSYLKELPDIDESRNPILKRLLSGSFLRRDGSTTVNVRVPARELVRLLSLTPEQQREGVSAKVRLINLLDPKYSVYEPYLYREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNGNIGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEEGKARPFRYKQNRL |
Expression
Developmental stage
Expressed in tachyzoites and bradyzoites; expression increases following the tachyzoite to bradyzoite conversion (at protein level).
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 39-58 | Disordered | ||||
Sequence: HGQFPSLRRTEGVSQSGSGH | ||||||
Domain | 48-354 | Protein kinase | ||||
Sequence: TEGVSQSGSGHKGSVYRIPLADMTFWSWMSYLKELPDIDESRNPILKRLLSGSFLRRDGSTTVNVRVPARELVRLLSLTPEQQREGVSAKVRLINLLDPKYSVYEPYLYREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNGNIGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIMKDPLF |
Domain
The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length377
- Mass (Da)42,203
- Last updated2021-04-07 v1
- ChecksumEEF70B974FD5C666
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 311 | in Ref. 4 | ||||
Sequence: I → L |
Keywords
- Technical term