A0A7J6KCZ5 · A0A7J6KCZ5_TOXGO

  • Protein
    Transketolase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 1 Mg2+ ion per subunit. Can also utilize other divalent metal cations, such as Ca2+, Mn2+ and Co2+.
thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site57substrate
Site57Important for catalytic activity
Binding site292substrate
Site292Important for catalytic activity
Binding site389substrate
Binding site416substrate
Binding site492substrate
Binding site500substrate
Binding site504substrate
Binding site552substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity
Biological Processpentose-phosphate shunt

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Transketolase
  • EC number

Gene names

    • ORF names
      TGRH88_008240

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RH-88
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma

Accessions

  • Primary accession
    A0A7J6KCZ5

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-28Disordered
Domain386-557Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    699
  • Mass (Da)
    76,921
  • Last updated
    2021-04-07 v1
  • Checksum
    E42A038C0A7D5F2D
MPQKRRGSNAHLGEANNQPEKKKVSPGKTELGATDVLCVNTIRCLGADLPTIANSGHPGAPMGMAAMAHALWGYVLRHSGKHPQWFNRDRFVLSNGHACALLYSMLHLTGYDMSLEDLRQFRQLHSKTPGHPEAHYAAGIETTTGPLGQGISNAVGLALASEYMSAKFNKDGFPLFDNHVFVFCGDGCLEEGVSSEACSLAGHLGLHRLTVLYDDNNITIDGELHLAFSEKVQQRFKAYDWHVDVVEDGNTDVAGLVQAMENAKKRTDKPTLICVRTTIGFLSSKAGTAKVHGSPLSEEELRAVKEQCGLSPDEKLQIPEEVKQFYAQVQERGERSVEAWNALFERYKKEYPSEGEEIERMFSHKLRPEVLETLKTLGEKAKEKADSTRAHSGRMLLGIKDFMPELIGGSADLTGSNCTDLKEPSFQVANRSGRYIHFGVREHAMIAMANGLYHFGCMRPFCATFLNFVTYGWGAVRLAALSKCGVLVVATHDSIELGQDGPTHQPIEVLALCRATPNLIAIRPADGTEVAGAYAVWLRDELKRVTVLSLCRSSVPVLQGSSFDGVIKGAYVLSDFENNGKKKVVIAGSGSEVHFCVEAKKLLTNNWDVRLVSMPCWTLFDEQPAEYRNQVLCLSERRQGKVLTAYVEAASPFGWEKYFDVHVGLPTFGGSAPAKALYEFFGFSPANIAKRIEEFQAPF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAUHK010000189
EMBL· GenBank· DDBJ
KAF4645008.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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