A0A7J6K7I9 · WNG2_TOXGO

  • Protein
    Serine/threonine-protein kinase WNG2
  • Gene
    ROP34
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Probable serine/threonine-protein kinase.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for site, binding site, active site.

155350100150200250300350400450500550
TypeIDPosition(s)Description
Site111-112Cleavage; by ASP5
Binding site186ATP (UniProtKB | ChEBI)
Active site278Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase WNG2
  • EC number
  • Alternative names
    • Rhoptry kinase family protein ROP34
    • With-No-Gly-loop kinase 2

Gene names

    • Name
      ROP34
    • Synonyms
      WNG2
    • ORF names
      TGRH88_030990

Organism names

  • Taxonomic identifier
  • Strain
    • RH-88
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Toxoplasma

Accessions

  • Primary accession
    A0A7J6K7I9

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasmic granule
Secreted
Note: In tachyzoites, localizes to dense granules.

Keywords

Phenotypes & Variants

Disruption phenotype

In BALB/c mice infected with knockout tachyzoites (type I strain RH), virulence is not affected.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis109Loss of proteolytic cleavage by ASP5.

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-64
ChainPRO_000045680565-553Serine/threonine-protein kinase WNG2

Expression

Developmental stage

Expressed in tachyzoites (at protein level).

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-20Disordered
Region88-107Disordered
Domain125-395Protein kinase
Region432-553Disordered
Compositional bias468-553Basic and acidic residues

Domain

The protein kinase domain has an atypical kinase fold which lacks the glycine-rich loop that is critical for ATP binding in canonical protein kinase domains.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    553
  • Mass (Da)
    61,601
  • Last updated
    2021-04-07 v1
  • Checksum
    7C9CFD8CE368EA04
MMFPAVAAPPRRLPGERLQRSQNPVETSWLSFRILATRGPCVTSTFLFLTVAFLGLSWVSVAVAAHAEHPEDSATNFLFSFAENSLANREPPEDSAARPSSRSGGAERRRLDSLIPGFLKRRRIFKQLRPVDEFQLREFQEASSKVKAQFFSAGHSKVTFVDRPSAALLSFLHLEEEDVPYGVVIKAIPYDAFDFYESVAEPYIHRMFDDPRKFPYVVPVLAALRSTSKRVLYLVLPLYRELPETVDEEARSLDFVLLLAEMAMAVCQLHERNLAHRDLKEDNFLVSPEGHIVVSDLATLDITDNKSFLIGTSGYMPPETRSSYLLRKGYKRSRYGEKTDVYSLGVAFRHLAFMLEGLGVQVPHRTQLAKLIKKMTSPDPEKRPLIGEVMEDPFFASVDFRLVRQRAGKHPFKKLPGADLLAERQRARLEAREKADAAAKAADNAEVPAAKSPAGKTGGAGTLSGDRDRAGSGEKPAERAEEEKGRGRGAQTHEGNHDRTDDAGREELREGPGDQKPSGEENREGGQPPGQREEQREGTGLEEGFNKEDAQES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias468-553Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAUHK010000192
EMBL· GenBank· DDBJ
KAF4643433.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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