A0A7J6HWR9 · FPPS1_CANSA

Function

function

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Sesquiterpene biosynthesis.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site47isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site50isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site85isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site92Mg2+ 1 (UniProtKB | ChEBI)
Binding site92Mg2+ 2 (UniProtKB | ChEBI)
Binding site96Mg2+ 1 (UniProtKB | ChEBI)
Binding site96Mg2+ 2 (UniProtKB | ChEBI)
Binding site101dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site102isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site188dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site189dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site227dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site244dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site253dimethylallyl diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functiondimethylallyltranstransferase activity
Molecular Functiongeranyltranstransferase activity
Molecular Functionmetal ion binding
Biological Processcholesterol biosynthetic process
Biological Processfarnesyl diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Farnesyl pyrophosphate synthase 1
  • EC number
  • Short names
    CsFPPS1
    ; FPP synthase 1
  • Alternative names
    • (2E,6E)-farnesyl diphosphate synthase
    • Dimethylallyltranstransferase
      (EC:2.5.1.1
      ) . EC:2.5.1.1 (UniProtKB | ENZYME | Rhea)
    • Farnesyl diphosphate synthase
    • Geranyltranstransferase

Gene names

    • Name
      FPPS1
    • ORF names
      F8388_021429
      , G4B88_010567
      , G4B88_022528

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Finola
    • cv. Purple Kush TPS13
    • cv. Jamaican Lion 4
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Cannabaceae > Cannabis

Accessions

  • Primary accession
    A0A7J6HWR9
  • Secondary accessions
    • A0A1V0QSH0
    • A0A7J6G880
    • A0A803NYK3

Proteomes

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004608921-340Farnesyl pyrophosphate synthase 1

Expression

Tissue specificity

Mainly expressed in trichomes and flowers, and, to a lower extent, in leaves, roots and stems.

Family & Domains

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    340
  • Mass (Da)
    39,179
  • Last updated
    2021-04-07 v1
  • Checksum
    F1FA82D2CFA5932E
MADLKAKFLNVYSVLKSELLQDPAFEFTDISRQWVERMTDYNVPGGKLNRGLSVIDSYKLLKGEELTEEEIFLASALGWCIEWLQAYFLVLDDIMDNSHTRRGQPCWYKVPKVGMIAANDGVLLRNHIFRILKNHFKDKPYYVDLLDLFNEVEFQTASGQMLDLISSEGENDLSKFSLSLHRRIVQYKTAYYSFYLSVACALLMSGENLEDHVDVKNILVQMGIYFQVQDDYLDCFVDPKILGKIGTDIEDFKCSWLVVKALELSNEEQKKILNENYGKADPEKVAKVKALYKELDLEGEFADYESKSYEKLITSIESHPSKAVQAVLKSFLGKIYKRQK

Sequence caution

The sequence ARE72267.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict65in Ref. 2; KAF4379173

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY014571
EMBL· GenBank· DDBJ
ARE72267.1
EMBL· GenBank· DDBJ
mRNA Different initiation
JAATIP010000132
EMBL· GenBank· DDBJ
KAF4368817.1
EMBL· GenBank· DDBJ
Genomic DNA
JAATIQ010000021
EMBL· GenBank· DDBJ
KAF4399445.1
EMBL· GenBank· DDBJ
Genomic DNA
JAATIQ010000130
EMBL· GenBank· DDBJ
KAF4379173.1
EMBL· GenBank· DDBJ
Genomic DNA
UZAU01000235
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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