A0A7J6HWR9 · FPPS1_CANSA
- ProteinFarnesyl pyrophosphate synthase 1
- GeneFPPS1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids340 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Catalytic activity
- isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphateThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 Mg2+ ions per subunit.
Pathway
Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Sesquiterpene biosynthesis.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 47 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 50 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 85 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 92 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 92 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 96 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 96 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 101 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 102 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 188 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 189 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 227 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 244 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 253 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | dimethylallyltranstransferase activity | |
Molecular Function | geranyltranstransferase activity | |
Molecular Function | metal ion binding | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | farnesyl diphosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFarnesyl pyrophosphate synthase 1
- EC number
- Short namesCsFPPS1 ; FPP synthase 1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Cannabaceae > Cannabis
Accessions
- Primary accessionA0A7J6HWR9
- Secondary accessions
Proteomes
Genome annotation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000460892 | 1-340 | Farnesyl pyrophosphate synthase 1 | ||
Expression
Tissue specificity
Mainly expressed in trichomes and flowers, and, to a lower extent, in leaves, roots and stems.
Structure
Sequence
- Sequence statusComplete
- Length340
- Mass (Da)39,179
- Last updated2021-04-07 v1
- ChecksumF1FA82D2CFA5932E
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 65 | in Ref. 2; KAF4379173 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY014571 EMBL· GenBank· DDBJ | ARE72267.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
JAATIP010000132 EMBL· GenBank· DDBJ | KAF4368817.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAATIQ010000021 EMBL· GenBank· DDBJ | KAF4399445.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAATIQ010000130 EMBL· GenBank· DDBJ | KAF4379173.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UZAU01000235 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |