A0A7J5XHQ7 · A0A7J5XHQ7_DISMA
- ProteinPalmitoyl-protein thioesterase ABHD10, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids827 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.
Catalytic activity
- S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | hydrolase activity, hydrolyzing O-glycosyl compounds | |
Molecular Function | palmitoyl-(protein) hydrolase activity | |
Biological Process | protein depalmitoylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyl-protein thioesterase ABHD10, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Notothenioidei > Nototheniidae > Dissostichus
Accessions
- Primary accessionA0A7J5XHQ7
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: MTGEWESTEARDGPFHSPLPPAMQSLDWNTPAGTEDI | ||||||
Compositional bias | 23-37 | Polar residues | ||||
Sequence: MQSLDWNTPAGTEDI | ||||||
Domain | 600-703 | AB hydrolase-1 | ||||
Sequence: VLFLPGYASNMNGQKAEALEEFCRSLGHSYLRFDYTGHGASEGVLSEGTIGTWKKDVLYVLDELVEGPQIMVGSSLGGWLMLLAAIARPEKTAALVGISTAADH |
Sequence similarities
Belongs to the AB hydrolase superfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length827
- Mass (Da)87,762
- Last updated2021-04-07 v1
- Checksum1380B495A865F861
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-37 | Polar residues | ||||
Sequence: MQSLDWNTPAGTEDI |
Keywords
- Technical term