A0A7J5XHQ7 · A0A7J5XHQ7_DISMA

Function

function

Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionhydrolase activity, hydrolyzing O-glycosyl compounds
Molecular Functionpalmitoyl-(protein) hydrolase activity
Biological Processprotein depalmitoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Palmitoyl-protein thioesterase ABHD10, mitochondrial
  • EC number
  • Alternative names
    • Acyl-protein thioesterase ABHD10
    • Alpha/beta hydrolase domain-containing protein 10
    • Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Gene names

    • ORF names
      F7725_029058

Organism names

  • Taxonomic identifier
  • Strain
    • DM0001
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Notothenioidei > Nototheniidae > Dissostichus

Accessions

  • Primary accession
    A0A7J5XHQ7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-37Disordered
Compositional bias23-37Polar residues
Domain600-703AB hydrolase-1

Sequence similarities

Belongs to the AB hydrolase superfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    827
  • Mass (Da)
    87,762
  • Last updated
    2021-04-07 v1
  • Checksum
    1380B495A865F861
MTGEWESTEARDGPFHSPLPPAMQSLDWNTPAGTEDISQPLNSISSLTTASVSPHIIAAAQESSYKLGRLTLIAPESCGSTTSASHPAIIVSVGVGGLEKKEGFAAYGKALYCVSGAEDVWMKPDVVASSSGLTVKEAILPIVVKPFVTSALKRHFLSVPGVSHRLVVIVLQPDVSQLVVGHVFDERPLHLELALPLVLRPDARVGIVVHRGAHLGHAAEVPAAVDAEQQVQGALVAQRAVGTVQTLVAMFCAAPDGVLDGAVDVVFRIALDNENAPVFQAPVKVFGVVVVEGAQLLQHGVHLTGAGGGTQGDSPNHTEALTTVPGSHPAVGGWTGLLGLLLMEGLWGARLRGEVHPLSSQVPMFILCFMGGGGMAPPPIPMLALGLTFGCGLAGFLAMAAQEAGFGAEELTGGGRLLAAMLLIPAVPSGEPTVLVTAATMSVPSFKPHRDFTQLGVASKARLSVRDGPTQRAGGVTVAVTVDRALGGLALRDTGSPGGKVCITREEVEAMLAQEGGGVPQGTGLAKHTVREEVRLAIAHLSIGGQWVAEQYGSRRAEVLPQRTFTDFKSPETQVHSPVCLRPDLPKLAYRRVKGKSPGVLFLPGYASNMNGQKAEALEEFCRSLGHSYLRFDYTGHGASEGVLSEGTIGTWKKDVLYVLDELVEGPQIMVGSSLGGWLMLLAAIARPEKTAALVGISTAADHIVTVYNSLSLEARKEFEEKGEWTLPTKHPEEGLYDFNMDFLKEAENHCVLQSPIPITCPVRLIHGLKDEDVPWHISMQVAERILSADVDVILRRQGQHRMSERDDIKLMVYTIDDLIDKLTTMV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias23-37Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAKFY010000024
EMBL· GenBank· DDBJ
KAF3836500.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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