A0A7J0FPW7 · A0A7J0FPW7_9ERIC

  • Protein
    UMP-CMP kinase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per monomer.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site32-37ATP (UniProtKB | ChEBI)
Binding site58a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site79-81a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site106-109a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site113CMP (UniProtKB | ChEBI)
Binding site145ATP (UniProtKB | ChEBI)
Binding site149a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site160a ribonucleoside 5'-phosphate (UniProtKB | ChEBI)
Binding site188ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular Componentchromosome, centromeric region
Cellular ComponentCtf18 RFC-like complex
Cellular Componentcytoplasm
Molecular Function(d)CMP kinase activity
Molecular FunctionATP binding
Molecular Functionhydrolase activity
Molecular FunctionUMP kinase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processmaintenance of mitotic sister chromatid cohesion
Biological Processphosphorylation
Biological Processpyrimidine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UMP-CMP kinase
  • EC number
  • Alternative names
    • Deoxycytidylate kinase
      (CK
      ; dCMP kinase
      )
    • Uridine monophosphate/cytidine monophosphate kinase
      (UMP/CMP kinase
      ; UMP/CMPK
      )

Gene names

    • ORF names
      Acr_14g0003940

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • cv. Fuchu
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > Ericales > Actinidiaceae > Actinidia

Accessions

  • Primary accession
    A0A7J0FPW7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the DCC1 family.
Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    614
  • Mass (Da)
    70,342
  • Last updated
    2021-04-07 v1
  • Checksum
    9AF38710B390FE56
METAIDSANKEANGISLSEKKVTVVFVLGGPGSGKGTQCANIVQHFGFTHLSAGDLLRAEIKSGSENGTMIQNMIKDGKIVPSEVTVKLLQRAMQDSSNDKFLIDGFPRNEENRAAFESVTGIDPEFVLFFECPEEEMERRLLSRNQGREDDNIDTVRKRFKVYMESSLPVIEYYIAKGKVRKIEAAKPVKEVFEAVKTIFTPLKEKELYLIDCKKPVELIEAAMEMETEQQLSTCRGAEAVLNLQPASSVSIAYHSLFGPHDDLVLLELDEKLLPDVLHNSLMKMQFFVLRPKHMPLSMSEPPTLYCLYRLQINHCCVEMHKILMRKIVSRNWWHQSSKWHLVSWKLFEVAPRIDRLKMLLSENPYRFDDALMSEELDEMEKNNTRLYSWSDLIDKVQASADELRSGLQALSAVEIDGYWRIVDENYMDGILNMLLHNSVLNDWSLNGLNEAEVVGVLQSDGFPCEIAHHCLQVYGSKMDDGMWRLDEKRVCIHFARGILRGGKIRMDNFMVEWMRKIPEEMQASFDMLTGEVLTEKLGIETWVYAFSVSSLPSAPAERFSMLFRERPKWEWKDLQPYIRDLSVPGLSSEGLLLKYTRRTQPTPDAEPVFSAR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BJWL01000014
EMBL· GenBank· DDBJ
GFZ00759.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp