A0A7I9ZYL8 · A0A7I9ZYL8_9BACE

  • Protein
    Aspartate-semialdehyde dehydrogenase
  • Gene
    asd
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site9-12NADP+ (UniProtKB | ChEBI)
Binding site37-38NADP+ (UniProtKB | ChEBI)
Binding site98phosphate (UniProtKB | ChEBI)
Active site128Acyl-thioester intermediate
Binding site155substrate
Binding site158-159NADP+ (UniProtKB | ChEBI)
Binding site180NADP+ (UniProtKB | ChEBI)
Binding site233substrate
Active site240Proton acceptor
Binding site313NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionaspartate-semialdehyde dehydrogenase activity
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionprotein dimerization activity
Biological Process'de novo' L-methionine biosynthetic process
Biological Processdiaminopimelate biosynthetic process
Biological Processisoleucine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aspartate-semialdehyde dehydrogenase
  • EC number
  • Short names
    ASA dehydrogenase
    ; ASADH
  • Alternative names
    • Aspartate-beta-semialdehyde dehydrogenase

Gene names

    • Name
      asd
    • ORF names
      E4T97_02275
      , IMSAGC001_00493

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • P2318
    • IMSAGC_001
  • Taxonomic lineage
    Bacteria > Bacteroidota > Bacteroidia > Bacteroidales > Bacteroidaceae > Bacteroides

Accessions

  • Primary accession
    A0A7I9ZYL8

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-118Semialdehyde dehydrogenase NAD-binding

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    335
  • Mass (Da)
    37,097
  • Last updated
    2021-04-07 v1
  • Checksum
    61850A313B26DE9E
MKVAIVGVSGAVGQEFLRVLDERNFPLDELVLFGSKRSAGTTYTFRGKQIEVKLLQHNDDFKGVDIAFTSAGAGTSKEFEKTITKYGAVMIDNSSAFRMDADVPLVVPEVNAEDALERPRGVIANPNCTTIQMVVALKAIEKLSHIKTVHVSTYQAASGAGAAAMDELYEQYRQVLANEPVTVEKFAYQLAFNLIPQIDVFTENGYTKEEMKMYNETRKIMHSDVKVSATCVRVPALRAHSESIWIETERPISVEEAREAFANGEGLVLQDNPAEKEYPMPLFLAGKDPVYVGRIRKDLTNENGLTFWIVGDQIKKGAALNAVQIAEYLIKVKNI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BLLS01000006
EMBL· GenBank· DDBJ
GFH85097.1
EMBL· GenBank· DDBJ
Genomic DNA
SPPV01000003
EMBL· GenBank· DDBJ
TFU52244.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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