A0A7I8V7X9 · A0A7I8V7X9_9ANNE
- ProteinNADH-cytochrome b5 reductase 2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids843 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H+ + NAD+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 246 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 635 | FAD (UniProtKB | ChEBI) | ||||
Sequence: P | ||||||
Binding site | 636 | FAD (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 651 | FAD (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 653 | FAD (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 668 | FAD (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 669 | FAD (UniProtKB | ChEBI) | ||||
Sequence: M | ||||||
Binding site | 670 | FAD (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 727 | FAD (UniProtKB | ChEBI) | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | ATP binding | |
Molecular Function | cytochrome-b5 reductase activity, acting on NAD(P)H | |
Molecular Function | FAD binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-cytochrome b5 reductase 2
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Annelida > Polychaeta > Polychaeta incertae sedis > Dinophilidae > Dimorphilus
Accessions
- Primary accessionA0A7I8V7X9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 116-141 | Helical | ||||
Sequence: WKIIVISICCFVFAIIIVCSTVFYIW | ||||||
Transmembrane | 547-569 | Helical | ||||
Sequence: VLPIAVAVGAVVVSAVLAKIFLF |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-96 | Ig-like | ||||
Sequence: PVIIKRPNNKTVHLGQNVTIHCEANRNGRVYWKKYDNFTRQFKLLGSAERGKYEQRNKSTVLVVFNFSAEEDAVYLCTTSASRNHPDRTVY | ||||||
Domain | 214-480 | Protein kinase | ||||
Sequence: MDLGNLIGQGAFGQVFKADLSQLHGSIPVAVKKLRENATDRDVIDMWKEFERMKTIGSHINIISLVGYTTFEGNMYLITEYAEHGNLQLYLRRHSPPAGSDGILDYKDLVHLAWQIARGMEYLSNRQCIHRDLAARNVLVASNGVAKIADFGLSRDLTETEYYRLRPGGRIPIKWVPPETLFDFKFTIMSDVWAYGVVLWEIFSYGAEPYEDHEPAALFVLLNNGYRMPKAKYMSDEIAEIMTMCWKEDPNARPYFSAISSATDKII | ||||||
Region | 495-530 | Disordered | ||||
Sequence: SVDEESDELTQLLSRSATETKSPRASSSDSQYSSMP | ||||||
Compositional bias | 505-530 | Polar residues | ||||
Sequence: QLLSRSATETKSPRASSSDSQYSSMP | ||||||
Domain | 582-694 | FAD-binding FR-type | ||||
Sequence: SVKYPLKLVYKEDISHDTRLFRFALPSNEHILGLPTGQHIYLSCRIDNEPVVKPYTPVSSDEDLGKVDLVVKIYKANVHPKFPNGGKMSQYLDAMSIGDSIDFRGPNGKLVYE |
Sequence similarities
Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length843
- Mass (Da)96,386
- Last updated2021-04-07 v1
- ChecksumCE59EE36210825A3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 505-530 | Polar residues | ||||
Sequence: QLLSRSATETKSPRASSSDSQYSSMP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAJFCJ010000001 EMBL· GenBank· DDBJ | CAD5111384.1 EMBL· GenBank· DDBJ | Genomic DNA |