A0A7I8DJX8 · A0A7I8DJX8_9FIRM

  • Protein
    DNA-directed RNA polymerase subunit beta'
  • Gene
    rpoC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site69Zn2+ 1 (UniProtKB | ChEBI)
Binding site71Zn2+ 1 (UniProtKB | ChEBI)
Binding site84Zn2+ 1 (UniProtKB | ChEBI)
Binding site87Zn2+ 1 (UniProtKB | ChEBI)
Binding site458Mg2+ (UniProtKB | ChEBI)
Binding site460Mg2+ (UniProtKB | ChEBI)
Binding site462Mg2+ (UniProtKB | ChEBI)
Binding site804Zn2+ 2 (UniProtKB | ChEBI)
Binding site887Zn2+ 2 (UniProtKB | ChEBI)
Binding site894Zn2+ 2 (UniProtKB | ChEBI)
Binding site897Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionmagnesium ion binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit beta'
  • EC number
  • Short names
    RNAP subunit beta'
  • Alternative names
    • RNA polymerase subunit beta'
    • Transcriptase subunit beta'

Gene names

    • Name
      rpoC
    • ORF names
      bsdcttw_03460

Organism names

Accessions

  • Primary accession
    A0A7I8DJX8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Domain233-512RNA polymerase N-terminal
Coiled coil385-412
Region1202-1242Disordered
Compositional bias1207-1242Acidic residues

Sequence similarities

Belongs to the RNA polymerase beta' chain family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,242
  • Mass (Da)
    138,871
  • Last updated
    2021-04-07 v1
  • Checksum
    BEE7D141ED43A115
MMPEVVNNQSNQEITYDAIKIGLASPEKIREWSRGEVKKPETINYRTLKPEKDGLFCEKIFGPSKDWECHCGKYKKIRYKGVVCDRCGVEVTKASVRRERMGHIELAAPVSHIWYFKGIPSRMGLILDLSPRTLEKVLYFASYIVLDKGTSDLQYKQVLNEKEYREAYEKYGNRFRVGMGAEAIQELLMAIDLEAESKELKKGLKDFTGQKRARVIKRLEVVEAFRESGNRPDWMILTVVPVIPPDLRPMVQLDGGRFATSDMNDLYRRIINRNNRLKRLLELGAPDIIVRNEKRMLQEAVDALIDNGRRGRPVTGPGNRALKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKIYQCGLPKEMAIELFKPFVMKELVAKGTAHNIKSAKKMVERLQSEVWDVLEEVIREHPVMLNRAPTLHRLGIQAFEPVLVEGKAIKLHPLVCTAFNADFDGDQMAVHLPLSVEAQAECRFLLLSPNNLLKPSDGGPVAVPSQDMVLGIYYLTLQKPGDLGEGHFFKSVNEAILAYENGAITLHARIKVRRTGINSEGVTITKTIESTLGRFIFNEIISQDLGFVDRTNSDNFLVPEVDFHVGKKQLKKILEKCINTHGATKTAETLDAIKSLGYKYSTRAAMTVSISDMTVPPQKKIIIAEAESRVEEISKNFRRGLMTEDERHKAVIDTWKVADDDITEALLTGLDKYNNIYMMADSGARGSDKQIKQLAGMRGLMADTSGRTLELPIKSNFREGLDVLEYFMSAHGARKGLSDTALRTADSGYLTRRLVDVSQDLIIREVDCCEGKEIPGMWIKAFADGSEVIESLEERITGRYSCETIQDDNGEVIVKANHMITPKRAAKIVATQKISEQGFNAKIKIRTILTCKSHIGVCAKCYGANMATGEAVQVGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRVEELFEARKPKGLAIIAEFGGVVTIKDTKKKREVIVTNNETGEAKTYLIPYGSRIKVLDGDVLEAGDELTEGSVNPHDILKIKGVRAVQDYMIQEVQRVYRLQGVEINDKHIEVIVRQMLKKIRIENSGDSEFLPGKLVDILEFEDVNEELESKGLPIADGKQVMLGITKASLATNSFLSAASFQETTKVLTEAAINGKIDPLIGLKENVIIGKLIPAGTGMKRYRSVKLDSDMEEEILLSEDFDDDNYQNFNYSDDAMDDDLDSIDLDEFEDEDFSEEDFENDESLDDSDK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1207-1242Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023368
EMBL· GenBank· DDBJ
BCJ97305.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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