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A0A7I7NWQ7 · A0A7I7NWQ7_9MYCO

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

1774100200300400500600700
TypeIDPosition(s)Description
Binding site94ATP (UniProtKB | ChEBI)
Binding site112-116ATP (UniProtKB | ChEBI)
Binding site501ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA2
    • Synonyms
      secA
    • ORF names
      MSEO_14040

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 16018
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium

Accessions

  • Primary accession
    A0A7I7NWQ7

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain13-583SecA family profile
Region28-47Disordered
Domain96-255Helicase ATP-binding
Domain426-588Helicase C-terminal

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    774
  • Mass (Da)
    84,846
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    64C5B7F5A8F54F45322F3042FC034BC4
MPKTTRAQPGRLSSRFWRLLGASTEKNRSRSLAQVTESSEYDEEAAGLSDEQLRKAAGLLDLDDLAESDDIPQFLAIAREAAERVTTLRPFDVQLLGALRMLAGDVIEMATGEGKTLSGAIAAAGYALAGRHVHVVTINDYLARRDAEWMGPLIEAMGLTVGWITAESTSEERRAAYGCDVTYASVNEIGFDVLRDQLVVDVADLVSPNPDVALIDEADSVLVDEALVPLVLAGTTHRETPRLEIIKLVGELSPETDYDTDSDSRNVHLTDVGARKVEKALGGIDLYSEEHVGTTLTEVNVALHAHVLLQRDVHYIVRDDAVHLINASRGRIAQLQRWPDGLQAAVEAKEGIETTETGEVLDTITVQALINRYETVCGMTGTALAAGEQLRQFYKLGVSPIPPNKPNIREDESDRVYITAAAKNDGIVAHIAEVHETGQPVLVGTRDVAESEELHERLLRRGVPAVVLNAKNDAEEAEVIAEAGKYGVVTVSTQMAGRGTDIRLGGSDEADHDRVAELGGLHVVGTGRHHTERLDNQLRGRAGRQGDPGSSVFFSSWEDDVVAANLDHNKLPMETDEDGRIVSPKAAGLLDHAQRVAEGRMLDVHANTWRYNQLIAQQRAIIVDRRNTLLRTATAREELAELAPKRYKELSKDIPEDRLETICRQIMLYHLDRGWADHLAYLADIRESIHLRALGRQNPLDEFHRLAVDAFASLAADAIEAAQQTFETANVLEEEQGLDLSKLARPTSTWTYMVNDNPLSDDTLSTLSLPGVFR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP022582
EMBL· GenBank· DDBJ
BBY00905.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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