A0A7I7NTB3 · A0A7I7NTB3_9MYCO

  • Protein
    3-isopropylmalate dehydratase large subunit
  • Gene
    leuC_1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Organic acid metabolism; propanoate degradation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site357[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site417[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site420[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2-methylisocitrate dehydratase activity
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC_1
    • Synonyms
      leuC
    • ORF names
      MSEO_03960

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • JCM 16018
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium

Accessions

  • Primary accession
    A0A7I7NTB3

Proteomes

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-467Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    476
  • Mass (Da)
    50,434
  • Last updated
    2021-04-07 v1
  • Checksum
    BBE96F53F0A2341C
MGSGKPRTLAEKVWDDHVVDRGADDPEQGGAPDLIYIDLHLVHEVTSPQAFDGLRLAGRPVRRPDLTLATEDHNVPTVDIDKPIADPVSRTQVETLRRNCAEFGVRLYPMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGALAMGIGTSEVEHVLATQTLPLRPFKTMAVNVDGELPAGVTAKDIILALIAKIGTGGGQGHVIEYRGSAIESLSMEGRMTICNMSIEAGARAGMVAPDATTYEFLRDKPHAPQGAQWDAAMRYWQRLHTDPGAAFDTEVHLDATSLSPFVTWGTNPAQGVPLAGAVPDPELMSGDAERQAAEKALAYMDLRPGTPMRDIAVDTVFVGSCTNGRIEDLRVVADVLRGRKLAPGLRMLVVPGSMRVRAQAEAEGLGEVFTAAGAEWRQAGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTLSAPADLN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP022582
EMBL· GenBank· DDBJ
BBX99896.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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