A0A7I6IUU8 · A0A7I6IUU8_TACFU

Function

function

Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1. In addition to autophagy, also plays a role in necrotic cell death.
Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentautophagosome membrane
Cellular Componentlate endosome membrane
Cellular Componentmitochondrion
Cellular Componentphagophore assembly site membrane
Biological Processautophagy of mitochondrion
Biological Processlipid transport
Biological Processprotein localization to phagophore assembly site

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 9

Gene names

    • Name
      ATG9A

Organism names

Accessions

  • Primary accession
    A0A7I6IUU8

Subcellular Location

Cytoplasmic vesicle, autophagosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein
Late endosome membrane
Mitochondrion membrane
; Multi-pass membrane protein
Preautophagosomal structure membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane59-84Helical
Transmembrane122-140Helical
Transmembrane286-310Helical
Transmembrane368-390Helical
Transmembrane402-421Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region580-607Disordered
Compositional bias586-607Polar residues
Region665-697Disordered
Region805-831Disordered

Sequence similarities

Belongs to the ATG9 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    831
  • Mass (Da)
    94,622
  • Last updated
    2021-04-07 v1
  • Checksum
    ADF2C71A510D5A1F
MAHFDTEYQRLEASYSDSPPGEENLLVHVPEGSKSHWHHIENLDLFFQRVYNLHQKNGFTCMLLGEIFELVQLVFVVTFTVFLANCVDYDILFANKFVNHTESSKVTLPDAFLPVDVCHDRIRDNVFVIFILVISGVFWLHRLVKFIYNVCCYWEIRSFYINALKISTADLPYFTWQEVQARIIEIQKEHQICIHKKELTELDIYHRILRFKNYMVAMVNKSLLPIRFRLPLLGDCVFYTRGLKYNFELIFFWGPGSLFENEWSLKSEYKRGGNRLDLADRLSSRILWIGIANLLLCPVILIWQILYAFFSYTEVIKREPGSLGARCWSLYGRCYLRHFNELDHELMSRLSKGYKASSKYMNCFMSPLLTVVAKNVAFFAGSILAVLIALTIYDEDVLSVEHVLSSITLLGVCITICRSFIPDKHMVFCPEQLLKVILAHIHYMPDHWQGNAHRYETRDEFAQLFQYKAVFILEELLSPVITPFILIFCLRRKSLEIIDFFRNFTVEVVGVGDTCSFAQMDVRHHGHPAWMSAGKTEASIYQQAEDGKTELSLMHFAITNPQWQPPRESTHFISQLKEKVHREATGGQQGTATENLTSAHSLQSESEPRSLVANLLAGPPSLASLHLGRDGSIINHMSMGVNEGASALRSLSPLSTSLHLRASYLSSRPPRPDHPAVAAGRAMAGSGTDARTISSGSSAWEGQLNSMVLSEYASTEMSIHALYMHEMHKKQSSVEISRHTWHRQESDESSESVHDYTETTRNLLPRSNTFPCNTTANQQGATVHSSVSQYGGTTGARVQRTARMPMGGWEEKSVAEEGSEDELPPHVHKVT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias586-607Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY062781
EMBL· GenBank· DDBJ
AQY15991.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help