A0A7I6H9J8 · A0A7I6H9J8_ECOHS

Function

function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.

Features

Showing features for binding site, active site.

142050100150200250300350400
TypeIDPosition(s)Description
Binding site227pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site268-271pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site271substrate
Binding site307substrate
Binding site311substrate
Active site342Proton donor
Binding site343substrate
Binding site378pyridoxal 5'-phosphate (UniProtKB | ChEBI)
Binding site378substrate

GO annotations

AspectTerm
Molecular Functiondiaminopimelate decarboxylase activity
Molecular Functionpyridoxal phosphate binding
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Diaminopimelate decarboxylase
  • EC number
  • Short names
    DAP decarboxylase
    ; DAPDC

Gene names

    • Name
      lysA
    • Ordered locus names
      EcHS_A2985

Organism names

Accessions

  • Primary accession
    A0A7I6H9J8

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue54N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain33-275Orn/DAP/Arg decarboxylase 2 N-terminal
Domain276-376Orn/DAP/Arg decarboxylase 2 C-terminal

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    420
  • Mass (Da)
    46,177
  • Last updated
    2021-04-07 v1
  • Checksum
    0A26ABCFAF8462B5
MPHSLFSTDTDLTAENLLRLPAEFGCPVWVYDAQIIRRQIAALKQFDVVRFAQKACSNIHILRLMREQGVKVDSVSLGEIERALAAGYNPQTHPDDIVFTADVIDQATLERVSELQIPVNAGSVDMLDQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWYTDLPAALDVIQRHHLQLVGIHMHIGSGVDYAHLEQVCGAMVRQVIEFGQDLQAISAGGGLSVPYQQGEEAVDTEHYYGLWNAAREQIARHLGHPVKLEIEPGRFLVAQSGVLITQVRSVKQMGSRHFVLVDAGFNDLMRPAMYGSYHHISALAADGRSLEHAPTVETVVAGPLCESGDVFTQQEGGNVETRALPEVKAGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALELL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000802
EMBL· GenBank· DDBJ
ABV07226.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp