Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
Role of complement factor B rs4151667 (L9H) polymorphisms and its interactional role with CFH Y402H and C3 rs2230199 (R102G) risk variants in age-related macular degeneration: a case control study.
we demonstrated that the complement factor B genes rs641153 and rs4151667 but not rs1048709 rs2072633 rs12614 were associated with the susceptibility of age-related macular degeneration and might play predictive roles in future age-related macular degeneration diagnosis.
The pooled ORs for rs551397 rs2274700 rs4151667 rs641153 rs1047286 rs9332739 and rs547154 in the heterozygote model were 0.53 0.53 0.54 0.48 1.42 0.50 and 0.52 respectively. We confirmed the protective role of C2/CFB/CFH polymorphisms in the development of Age-Related Macular Degeneration (AMD) and showed single nucleotide polymorphism in C3 was a high-risk factor for AMD
Heterozygous variants in the CFB gene can be pathogenic and associated with immune-complex diffuse membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome
target sequencing of age-related macular degeneration (AMD) susceptibility genes identified enrichment of low-frequency coding variants in CETP C2 and CFB are associated with AMD susceptibility in the Japanese population
These results suggest (i) apparent allelic heterogeneity in CFB and genetic heterogeneity in SLC44A4 across different ethnic groups; (ii) shared ulcerative colitis genetic etiological factors among Asians
The complement activation factors Bb C3a C5a and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027 <.001 .001 and <.001 respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014 respectively) compared with L-control.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.