A0A7I2YQQ3 · A0A7I2YQQ3_HUMAN
- Proteinfolate gamma-glutamyl hydrolase
- GeneGGH
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids289 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
(6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n) RHEA-COMP:14738 + (n-1) CHEBI:15377 = CHEBI:57453 + (n-1) CHEBI:29985
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 134 | Nucleophile | |||
Active site | 244 | ||||
Active site | 244 | Proton donor | |||
Active site | 246 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | gamma-glutamyl-peptidase activity | |
Biological Process | glutamine metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namefolate gamma-glutamyl hydrolase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7I2YQQ3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-20 | ||||
Chain | PRO_5029841548 | 21-289 | folate gamma-glutamyl hydrolase | ||
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length289
- Mass (Da)32,303
- Last updated2021-04-07 v1
- ChecksumBC1E90D183E4F68E
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q92820 | GGH_HUMAN | GGH | 318 | ||
A0A7I2V431 | A0A7I2V431_HUMAN | GGH | 46 | ||
A0A7I2V5M0 | A0A7I2V5M0_HUMAN | GGH | 93 | ||
A0A7I2V5P2 | A0A7I2V5P2_HUMAN | GGH | 245 | ||
A0A7I2V5X9 | A0A7I2V5X9_HUMAN | GGH | 271 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC120042 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |