A0A7I2V5A1 · A0A7I2V5A1_HUMAN
- ProteinAconitate hydratase, mitochondrial
- GeneACO2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids716 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Catalytic activity
- citrate = D-threo-isocitrate
Cofactor
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | aconitate hydratase activity | |
Molecular Function | metal ion binding | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAconitate hydratase, mitochondrial
- EC number
- Short namesAconitase
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7I2V5A1
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 594 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 552 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 559 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 67-503 | Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha | ||||
Sequence: EKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQMAMLQFISSGLSKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWKPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGREDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPDLAHPVAEVGKVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAG | ||||||
Region | 528-560 | Disordered | ||||
Sequence: DADELPKGEFDPGQDTYQHPPKDSSGQHVDVSP | ||||||
Compositional bias | 545-560 | Polar residues | ||||
Sequence: QHPPKDSSGQHVDVSP | ||||||
Domain | 578-647 | Aconitase A/isopropylmalate dehydratase small subunit swivel | ||||
Sequence: DLEDLQILIKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFAD |
Sequence similarities
Belongs to the aconitase/IPM isomerase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length716
- Mass (Da)78,461
- Last updated2021-04-07 v1
- ChecksumF43F8F2553E6CBE7
Computationally mapped potential isoform sequences
There are 16 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q99798 | ACON_HUMAN | ACO2 | 780 | ||
A2A274 | A2A274_HUMAN | ACO2 | 805 | ||
A0A7I2V2Y4 | A0A7I2V2Y4_HUMAN | ACO2 | 92 | ||
A0A7I2V3C8 | A0A7I2V3C8_HUMAN | ACO2 | 324 | ||
A0A7I2V3F1 | A0A7I2V3F1_HUMAN | ACO2 | 788 | ||
A0A7I2V3U0 | A0A7I2V3U0_HUMAN | ACO2 | 725 | ||
A0A7I2V3U7 | A0A7I2V3U7_HUMAN | ACO2 | 160 | ||
A0A7I2V499 | A0A7I2V499_HUMAN | ACO2 | 69 | ||
A0A7I2V4I8 | A0A7I2V4I8_HUMAN | ACO2 | 288 | ||
A0A7I2V538 | A0A7I2V538_HUMAN | ACO2 | 487 | ||
A0A7I2V586 | A0A7I2V586_HUMAN | ACO2 | 747 | ||
A0A7I2V614 | A0A7I2V614_HUMAN | ACO2 | 731 | ||
A0A7I2V5U4 | A0A7I2V5U4_HUMAN | ACO2 | 80 | ||
A0A7I2V5W7 | A0A7I2V5W7_HUMAN | ACO2 | 324 | ||
A0A7I2V5T4 | A0A7I2V5T4_HUMAN | ACO2 | 775 | ||
A0A7I2V6A6 | A0A7I2V6A6_HUMAN | ACO2 | 422 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 545-560 | Polar residues | ||||
Sequence: QHPPKDSSGQHVDVSP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL008582 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL023553 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |