A0A7I2V4G5 · A0A7I2V4G5_HUMAN
- ProteinNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
- GeneNDUFS2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids437 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nucleoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | NAD binding | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | quinone binding |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7I2V4G5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme. Interacts with NDUFAF3. Interacts with NDUFAF7. Interacts with CERS2.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 193-234 | NADH-quinone oxidoreductase subunit D | |||
Domain | 233-437 | NADH-quinone oxidoreductase subunit D | |||
Sequence similarities
Belongs to the complex I 49 kDa subunit family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length437
- Mass (Da)49,462
- Last updated2021-04-07 v1
- ChecksumBB4ACCDAAA274DF2
Computationally mapped potential isoform sequences
There are 17 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O75306 | NDUS2_HUMAN | NDUFS2 | 463 | ||
A0A7I2YQD8 | A0A7I2YQD8_HUMAN | NDUFS2 | 431 | ||
A0A7I2YQG7 | A0A7I2YQG7_HUMAN | NDUFS2 | 484 | ||
A0A7I2YQX7 | A0A7I2YQX7_HUMAN | NDUFS2 | 59 | ||
A0A7I2V2B9 | A0A7I2V2B9_HUMAN | NDUFS2 | 407 | ||
A0A7I2V2P1 | A0A7I2V2P1_HUMAN | NDUFS2 | 73 | ||
A0A7I2V3J6 | A0A7I2V3J6_HUMAN | NDUFS2 | 423 | ||
A0A7I2V410 | A0A7I2V410_HUMAN | NDUFS2 | 386 | ||
A0A7I2V517 | A0A7I2V517_HUMAN | NDUFS2 | 253 | ||
A0A7I2V4W5 | A0A7I2V4W5_HUMAN | NDUFS2 | 407 | ||
A0A7I2V4X8 | A0A7I2V4X8_HUMAN | NDUFS2 | 438 | ||
A0A7I2V596 | A0A7I2V596_HUMAN | NDUFS2 | 478 | ||
A0A7I2V5D5 | A0A7I2V5D5_HUMAN | NDUFS2 | 212 | ||
A0A7I2V5E2 | A0A7I2V5E2_HUMAN | NDUFS2 | 334 | ||
A0A7I2V5G4 | A0A7I2V5G4_HUMAN | NDUFS2 | 341 | ||
A0A7I2V5X7 | A0A7I2V5X7_HUMAN | NDUFS2 | 39 | ||
A0A7I2V630 | A0A7I2V630_HUMAN | NDUFS2 | 372 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL590714 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |