A0A7I2V490 · A0A7I2V490_HUMAN

  • Protein
    DNA (cytosine-5)-methyltransferase
  • Gene
    DNMT1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

116582004006008001,0001,2001,4001,600
Type
IDPosition(s)Description
Binding site353Zn2+ (UniProtKB | ChEBI)
Binding site356Zn2+ (UniProtKB | ChEBI)
Binding site414Zn2+ (UniProtKB | ChEBI)
Binding site418Zn2+ (UniProtKB | ChEBI)
Active site1226

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA (cytosine-5-)-methyltransferase activity
Molecular FunctionDNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA methylation-dependent heterochromatin formation
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA (cytosine-5)-methyltransferase
  • EC number

Gene names

    • Name
      DNMT1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A7I2V490

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,182 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)35PRIDEPhosphoserine
Modified residue (large scale data)127PRIDEPhosphoserine
Modified residue (large scale data)141PRIDEPhosphoserine
Modified residue (large scale data)143PRIDEPhosphoserine
Modified residue (large scale data)152PRIDEPhosphoserine
Modified residue (large scale data)154PRIDEPhosphoserine
Modified residue (large scale data)166PRIDEPhosphothreonine
Modified residue (large scale data)189PRIDEPhosphoserine
Modified residue (large scale data)192PRIDEPhosphoserine
Modified residue (large scale data)312PRIDEPhosphoserine
Modified residue (large scale data)394PRIDEPhosphoserine
Modified residue (large scale data)398PRIDEPhosphoserine
Modified residue (large scale data)399PRIDEPhosphotyrosine
Modified residue (large scale data)549PRIDEPhosphoserine
Modified residue (large scale data)714PRIDEPhosphoserine
Modified residue (large scale data)732PRIDEPhosphoserine
Modified residue (large scale data)878PRIDEPhosphoserine
Modified residue (large scale data)953PRIDEPhosphoserine
Modified residue (large scale data)954PRIDEPhosphoserine
Modified residue (large scale data)969PRIDEPhosphotyrosine
Modified residue (large scale data)1105PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain16-109DMAP1-binding
Region103-349Disordered
Compositional bias155-171Polar residues
Compositional bias175-271Basic and acidic residues
Compositional bias279-341Basic and acidic residues
Domain646-692CXXC-type
Region699-729Disordered
Domain755-880BAH
Domain972-1100BAH
Region1095-1130Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,658
  • Mass (Da)
    187,311
  • Last updated
    2021-04-07 v1
  • Checksum
    42CE15D61333C812
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQLCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRVGMADANSPPKPLSKPRTPRRSKSDGEAKPEPSPSPRITRKSTRQTTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPERAKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEKKHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVMNSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDLIKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDKENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQACEPSEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEGGSSGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESASGMVGWARLPLGPDCPLGVHVGAVAGHRFGLWDSGGSPTHVRGPIFLKGLL

Computationally mapped potential isoform sequences

There are 19 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P26358DNMT1_HUMANDNMT11616
K7EIZ6K7EIZ6_HUMANDNMT140
K7EKC3K7EKC3_HUMANDNMT125
K7EJL0K7EJL0_HUMANDNMT1255
K7ELB1K7ELB1_HUMANDNMT194
K7ENQ6K7ENQ6_HUMANDNMT1119
K7EMU8K7EMU8_HUMANDNMT189
K7ENW7K7ENW7_HUMANDNMT1389
K7EP77K7EP77_HUMANDNMT155
K7ER10K7ER10_HUMANDNMT177
K7ERQ1K7ERQ1_HUMANDNMT171
A0A7I2YQA8A0A7I2YQA8_HUMANDNMT11577
A0A7I2YQQ0A0A7I2YQQ0_HUMANDNMT11613
A0A7I2V2G5A0A7I2V2G5_HUMANDNMT1263
A0A7I2V311A0A7I2V311_HUMANDNMT11150
A0A7I2V3F8A0A7I2V3F8_HUMANDNMT1184
A0A7I2V5F1A0A7I2V5F1_HUMANDNMT11580
A0A7I2V5F6A0A7I2V5F6_HUMANDNMT11114
A0A7I2V5D0A0A7I2V5D0_HUMANDNMT11655

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias155-171Polar residues
Compositional bias175-271Basic and acidic residues
Compositional bias279-341Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC010077
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC011511
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC020931
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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