A0A7I2V490 · A0A7I2V490_HUMAN
- ProteinDNA (cytosine-5)-methyltransferase
- GeneDNMT1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1658 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 353 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 356 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 414 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 418 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 1226 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | DNA (cytosine-5-)-methyltransferase activity | |
Molecular Function | DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | DNA methylation-dependent heterochromatin formation | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA (cytosine-5)-methyltransferase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A7I2V490
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,182 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 35 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 127 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 141 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 143 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 152 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 154 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 166 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 189 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 192 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 312 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 394 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 398 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 399 | PRIDE | Phosphotyrosine | |||
Modified residue (large scale data) | 549 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 714 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 732 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 878 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 953 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 954 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 969 | PRIDE | Phosphotyrosine | |||
Modified residue (large scale data) | 1105 | PRIDE | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 16-109 | DMAP1-binding | |||
Region | 103-349 | Disordered | |||
Compositional bias | 155-171 | Polar residues | |||
Compositional bias | 175-271 | Basic and acidic residues | |||
Compositional bias | 279-341 | Basic and acidic residues | |||
Domain | 646-692 | CXXC-type | |||
Region | 699-729 | Disordered | |||
Domain | 755-880 | BAH | |||
Domain | 972-1100 | BAH | |||
Region | 1095-1130 | Disordered | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,658
- Mass (Da)187,311
- Last updated2021-04-07 v1
- Checksum42CE15D61333C812
Computationally mapped potential isoform sequences
There are 19 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P26358 | DNMT1_HUMAN | DNMT1 | 1616 | ||
K7EIZ6 | K7EIZ6_HUMAN | DNMT1 | 40 | ||
K7EKC3 | K7EKC3_HUMAN | DNMT1 | 25 | ||
K7EJL0 | K7EJL0_HUMAN | DNMT1 | 255 | ||
K7ELB1 | K7ELB1_HUMAN | DNMT1 | 94 | ||
K7ENQ6 | K7ENQ6_HUMAN | DNMT1 | 119 | ||
K7EMU8 | K7EMU8_HUMAN | DNMT1 | 89 | ||
K7ENW7 | K7ENW7_HUMAN | DNMT1 | 389 | ||
K7EP77 | K7EP77_HUMAN | DNMT1 | 55 | ||
K7ER10 | K7ER10_HUMAN | DNMT1 | 77 | ||
K7ERQ1 | K7ERQ1_HUMAN | DNMT1 | 71 | ||
A0A7I2YQA8 | A0A7I2YQA8_HUMAN | DNMT1 | 1577 | ||
A0A7I2YQQ0 | A0A7I2YQQ0_HUMAN | DNMT1 | 1613 | ||
A0A7I2V2G5 | A0A7I2V2G5_HUMAN | DNMT1 | 263 | ||
A0A7I2V311 | A0A7I2V311_HUMAN | DNMT1 | 1150 | ||
A0A7I2V3F8 | A0A7I2V3F8_HUMAN | DNMT1 | 184 | ||
A0A7I2V5F1 | A0A7I2V5F1_HUMAN | DNMT1 | 1580 | ||
A0A7I2V5F6 | A0A7I2V5F6_HUMAN | DNMT1 | 1114 | ||
A0A7I2V5D0 | A0A7I2V5D0_HUMAN | DNMT1 | 1655 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 155-171 | Polar residues | |||
Compositional bias | 175-271 | Basic and acidic residues | |||
Compositional bias | 279-341 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC010077 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC011511 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC020931 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |