A0A7I2V3F3 · A0A7I2V3F3_HUMAN

Function

function

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasmic ribonucleoprotein granule
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Molecular FunctionDNA binding
Molecular FunctionRNA binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nucleolin

Gene names

    • Name
      NCL

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A7I2V3F3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 658 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)28PRIDEPhosphoserine
Modified residue (large scale data)34PRIDEPhosphoserine
Modified residue (large scale data)41PRIDEPhosphoserine
Modified residue (large scale data)42PRIDEPhosphoserine
Modified residue (large scale data)60PRIDEPhosphoserine
Modified residue (large scale data)67PRIDEPhosphoserine
Modified residue (large scale data)69PRIDEPhosphothreonine
Modified residue (large scale data)76PRIDEPhosphothreonine
Modified residue (large scale data)92PRIDEPhosphothreonine
Modified residue (large scale data)99PRIDEPhosphothreonine
Modified residue (large scale data)106PRIDEPhosphothreonine
Modified residue (large scale data)113PRIDEPhosphothreonine
Modified residue (large scale data)121PRIDEPhosphothreonine
Modified residue (large scale data)145PRIDEPhosphoserine
Modified residue (large scale data)153PRIDEPhosphoserine
Modified residue (large scale data)184PRIDEPhosphoserine
Modified residue (large scale data)325PRIDEPhosphothreonine
Modified residue (large scale data)328PRIDEPhosphoserine
Modified residue (large scale data)356PRIDEPhosphoserine
Modified residue (large scale data)367PRIDEPhosphothreonine
Modified residue (large scale data)443PRIDEPhosphoserine
Modified residue (large scale data)445PRIDEPhosphoserine
Modified residue (large scale data)467PRIDEPhosphoserine
Modified residue (large scale data)479PRIDEPhosphoserine
Modified residue (large scale data)481PRIDEPhosphoserine
Modified residue (large scale data)486PRIDEPhosphothreonine
Modified residue (large scale data)548PRIDEPhosphoserine
Modified residue (large scale data)565PRIDEPhosphoserine
Modified residue (large scale data)568PRIDEPhosphothreonine
Modified residue (large scale data)569PRIDEPhosphothreonine
Modified residue (large scale data)572PRIDEPhosphothreonine
Modified residue (large scale data)576PRIDEPhosphoserine
Modified residue (large scale data)593PRIDEPhosphoserine
Modified residue (large scale data)594PRIDEPhosphoserine
Modified residue (large scale data)604PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-303Disordered
Compositional bias24-43Acidic residues
Compositional bias145-171Acidic residues
Compositional bias184-210Acidic residues
Compositional bias234-272Acidic residues
Compositional bias273-299Basic and acidic residues
Domain307-383RRM
Domain369-451RRM
Domain471-545RRM
Domain557-632RRM
Compositional bias614-628Basic and acidic residues
Region614-695Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    695
  • Mass (Da)
    74,844
  • Last updated
    2021-04-07 v1
  • Checksum
    D559868960FEB000
MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE

Computationally mapped potential isoform sequences

There are 10 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P19338NUCL_HUMANNCL710
C9JLB1C9JLB1_HUMANNCL694
H7BY16H7BY16_HUMANNCL734
A0A7I2V2S8A0A7I2V2S8_HUMANNCL389
A0A7I2V2U7A0A7I2V2U7_HUMANNCL626
A0A7I2V349A0A7I2V349_HUMANNCL595
A0A7I2V428A0A7I2V428_HUMANNCL689
A0A7I2V506A0A7I2V506_HUMANNCL602
A0A7I2V5M5A0A7I2V5M5_HUMANNCL672
A0A7I2V699A0A7I2V699_HUMANNCL616

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias24-43Acidic residues
Compositional bias145-171Acidic residues
Compositional bias184-210Acidic residues
Compositional bias234-272Acidic residues
Compositional bias273-299Basic and acidic residues
Compositional bias614-628Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC017104
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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