A0A7I2V2N8 · A0A7I2V2N8_HUMAN

  • Protein
    non-specific serine/threonine protein kinase
  • Gene
    MARK3
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Catalytic activity

Features

Showing features for binding site.

1726100200300400500600700
TypeIDPosition(s)Description
Binding site90ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Molecular FunctionATP binding
Molecular Functionprotein serine/threonine kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    non-specific serine/threonine protein kinase
  • EC number

Gene names

    • Name
      MARK3

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A7I2V2N8

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 666 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)2PRIDEPhosphoserine
Modified residue (large scale data)42PRIDEPhosphoserine
Modified residue (large scale data)45PRIDEPhosphoserine
Modified residue (large scale data)193PRIDEPhosphothreonine
Modified residue (large scale data)197PRIDEPhosphoserine
Modified residue (large scale data)350PRIDEPhosphoserine
Modified residue (large scale data)351PRIDEPhosphoserine
Modified residue (large scale data)356PRIDEPhosphoserine
Modified residue (large scale data)359PRIDEPhosphoserine
Modified residue (large scale data)360PRIDEPhosphoserine
Modified residue (large scale data)362PRIDEPhosphoserine
Modified residue (large scale data)365PRIDEPhosphoserine
Modified residue (large scale data)372PRIDEPhosphoserine
Modified residue (large scale data)373PRIDEPhosphoserine
Modified residue (large scale data)378PRIDEPhosphoserine
Modified residue (large scale data)382PRIDEPhosphoserine
Modified residue (large scale data)400PRIDEPhosphotyrosine
Modified residue (large scale data)401PRIDEPhosphoserine
Modified residue (large scale data)418PRIDEPhosphoserine
Modified residue (large scale data)420PRIDEPhosphothreonine
Modified residue (large scale data)451PRIDEPhosphoserine
Modified residue (large scale data)473PRIDEPhosphothreonine
Modified residue (large scale data)481PRIDEPhosphoserine
Modified residue (large scale data)489PRIDEPhosphothreonine
Modified residue (large scale data)511PRIDEPhosphoserine
Modified residue (large scale data)518PRIDEPhosphothreonine
Modified residue (large scale data)522PRIDEPhosphoserine
Modified residue (large scale data)523PRIDEPhosphothreonine
Modified residue (large scale data)525PRIDEPhosphoserine
Modified residue (large scale data)527PRIDEPhosphoserine
Modified residue (large scale data)528PRIDEPhosphoserine
Modified residue (large scale data)531PRIDEPhosphothreonine
Modified residue (large scale data)545PRIDEPhosphoserine
Modified residue (large scale data)546PRIDEPhosphothreonine
Modified residue (large scale data)565PRIDEPhosphoserine
Modified residue (large scale data)567PRIDEPhosphoserine
Modified residue (large scale data)569PRIDEPhosphoserine
Modified residue (large scale data)583PRIDEPhosphoserine
Modified residue (large scale data)612PRIDEPhosphoserine
Modified residue (large scale data)616PRIDEPhosphoserine
Modified residue (large scale data)697PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-36Disordered
Compositional bias14-28Basic and acidic residues
Domain56-289Protein kinase
Domain308-347UBA
Compositional bias352-400Polar residues
Region352-628Disordered
Compositional bias470-530Polar residues
Compositional bias560-595Polar residues
Compositional bias596-628Basic and acidic residues
Domain677-726KA1

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    726
  • Mass (Da)
    81,256
  • Last updated
    2021-04-07 v1
  • Checksum
    F52C0D2F672E127D
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGRELFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL

Computationally mapped potential isoform sequences

There are 35 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P27448MARK3_HUMANMARK3753
J3KNR0J3KNR0_HUMANMARK3776
H0YNV4H0YNV4_HUMANMARK3643
H0YKP9H0YKP9_HUMANMARK3623
H0YJI9H0YJI9_HUMANMARK3789
H0YIY6H0YIY6_HUMANMARK3505
A0A7I2YQ84A0A7I2YQ84_HUMANMARK3108
A0A7I2YQ91A0A7I2YQ91_HUMANMARK3113
A0A7I2YQF4A0A7I2YQF4_HUMANMARK3640
A0A7I2YQF7A0A7I2YQF7_HUMANMARK3738
A0A7I2YQJ7A0A7I2YQJ7_HUMANMARK3102
A0A7I2V2E3A0A7I2V2E3_HUMANMARK3622
A0A7I2V2I9A0A7I2V2I9_HUMANMARK3554
A0A7I2V2J6A0A7I2V2J6_HUMANMARK3115
A0A7I2V2U9A0A7I2V2U9_HUMANMARK3790
A0A7I2V3B9A0A7I2V3B9_HUMANMARK3665
A0A7I2V3C6A0A7I2V3C6_HUMANMARK3529
A0A7I2V3I9A0A7I2V3I9_HUMANMARK3682
A0A7I2V3K2A0A7I2V3K2_HUMANMARK3507
A0A7I2V3Q1A0A7I2V3Q1_HUMANMARK399
A0A7I2V409A0A7I2V409_HUMANMARK3796
A0A7I2V3P5A0A7I2V3P5_HUMANMARK3535
A0A7I2V3X7A0A7I2V3X7_HUMANMARK3115
A0A7I2V483A0A7I2V483_HUMANMARK3111
A0A7I2V4K8A0A7I2V4K8_HUMANMARK3781
A0A7I2V4L1A0A7I2V4L1_HUMANMARK3373
A0A7I2V4G7A0A7I2V4G7_HUMANMARK3647
A0A7I2V549A0A7I2V549_HUMANMARK3664
A0A7I2V4T2A0A7I2V4T2_HUMANMARK3621
A0A7I2V4T5A0A7I2V4T5_HUMANMARK3100
A0A7I2V5G3A0A7I2V5G3_HUMANMARK3674
A0A7I2V5H7A0A7I2V5H7_HUMANMARK3157
A0A7I2V602A0A7I2V602_HUMANMARK3655
A0A7I2V639A0A7I2V639_HUMANMARK3689
A0A7I2V5Z7A0A7I2V5Z7_HUMANMARK336

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias14-28Basic and acidic residues
Compositional bias352-400Polar residues
Compositional bias470-530Polar residues
Compositional bias560-595Polar residues
Compositional bias596-628Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL133367
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456011
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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