A0A7H9EHU0 · A0A7H9EHU0_9LACO

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site41-43ATP (UniProtKB | ChEBI)
Binding site134Mg2+ (UniProtKB | ChEBI)
Binding site174Mg2+ (UniProtKB | ChEBI)
Active site197
Binding site224D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processphosphorylation
Biological Processpurine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      GTO87_00640

Organism names

  • Taxonomic identifier
  • Strain
    • 1A
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Ligilactobacillus

Accessions

  • Primary accession
    A0A7H9EHU0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-124Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    35,176
  • Last updated
    2021-02-10 v1
  • Checksum
    C152BD03766551B6
MENNTASLKLFALNSNPELSQKIAAELGADLCSASVKHFSDGEIQINIDESVRGADVFVVQSISDPVNENFMELMIMIDALRRASAETINVVIPYYGYARADRKARSREPITAKMVANFIQTAGADRVVSMDLHAGQLQGFFNIPVDHLLAIFTQVDYFKKIGLDKDVVVIAPDHSSAKKARNMAQLLKAPIAIIDKRDENSLETIHDQTVIGNVAGKNCIILDDMIDTGVRMTDAAKALKMANAKDIYACATHAVFSGKAVESLRDSDIKQVIVTDTIAIPEEKQFAQLKVLSVAPVFAQAISLIYHNQSVDSLFEQHEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP047418
EMBL· GenBank· DDBJ
QLL77268.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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