A0A7H8QBA7 · A0A7H8QBA7_9BACL
- ProteinMultifunctional fusion protein
- GenemsrB
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids368 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + CHEBI:57844 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ CHEBI:58772
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 62 | |||||
Sequence: C | ||||||
Active site | 342 | Nucleophile | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Molecular Function | peptide-methionine (S)-S-oxide reductase activity | |
Biological Process | protein modification process | |
Biological Process | protein repair | |
Biological Process | response to oxidative stress |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameMultifunctional fusion protein
Including 2 domains:
- Recommended namePeptide methionine sulfoxide reductase MsrA
- EC number
- Short namesProtein-methionine-S-oxide reductase
- Alternative names
- Recommended namePeptide methionine sulfoxide reductase MsrB
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Planococcaceae > Planococcus
Accessions
- Primary accessionA0A7H8QBA7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MKLKHACLLLLVVLLAGCSVPNFNNA | ||||||
Chain | PRO_5028997249 | 27-368 | Multifunctional fusion protein | |||
Sequence: GETTAAGSESRFPDNPNEGLTFDEENLKDIWLAGGCFWGVEAYMARVFGVYDVTSGYANGNTENPSYEDVTRRNTGHAETVHVRYDPERINLEKLLSHYFMIIDPTLLNQQGNDRGEQYRTGVYYKDEADRTIIEAVMANEAPKYDDPLVTEVEPLKHYYLAEEYHQDYLEKNPNGYCHVEFDSLEDQEVPALIDSALYPKPSDKELKATLTDAQYQVTQKNDTETAYSNEYWDNYEPGIYVDVATGEPLFSSRDKYDSKCGWPSFTQPIEPDVVTEHKDTSYNMVRIEIRSRSGDSHLGHVFNDGPKDKGGLRYCINSASILFIPEAEMEAEGYGYLKGLL |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 230-353 | MsrB | ||||
Sequence: DKELKATLTDAQYQVTQKNDTETAYSNEYWDNYEPGIYVDVATGEPLFSSRDKYDSKCGWPSFTQPIEPDVVTEHKDTSYNMVRIEIRSRSGDSHLGHVFNDGPKDKGGLRYCINSASILFIPE |
Sequence similarities
Belongs to the MsrA Met sulfoxide reductase family.
Belongs to the MsrB Met sulfoxide reductase family.
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.
In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)41,669
- Last updated2021-02-10 v1
- Checksum6C306F5DD048382E