A0A7H0DN45 · PG072_MONPV

  • Protein
    Probable FAD-linked sulfhydryl oxidase OPG072
  • Gene
    OPG072
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. The complete pathway for formation of disulfide bonds in intracellular virion membrane proteins sequentially involves thiol-disulfide transfer between OPG072, OPG128 and OPG088.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componentmembrane
Cellular Componentviral envelope
Cellular Componentvirion membrane
Molecular Functionthiol oxidase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable FAD-linked sulfhydryl oxidase OPG072
  • EC number
  • Alternative names
    • Sulfhydryl oxidase
      (EC:1.8.3.2
      ) . EC:1.8.3.2 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      OPG072
    • ORF names
      MPXVgp058

Organism names

Accessions

  • Primary accession
    A0A7H0DN45

Proteomes

Subcellular Location

Virion membrane
Host cytoplasm
Note: Associated with crescent membranes, immature virions (IV) and mature virions (MV).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-8Intravirion
Transmembrane9-25Helical
Topological domain26-95Virion surface

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00004576951-95Probable FAD-linked sulfhydryl oxidase OPG072
Disulfide bond43↔46Redox-active

Keywords

Expression

Induction

Expressed in the early phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with OPG128; this interaction involves formation of a transient disulfide-bonded intermediate, allowing disulfide bond transfer.

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-95ERV/ALR sulfhydryl oxidase

Sequence similarities

Belongs to the orthopoxvirus OPG072 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    95
  • Mass (Da)
    10,911
  • Last updated
    2022-10-12 v1
  • Checksum
    F4A2FDC41599FA51
MNPKHWGRAVWTIIFIVLSQAGLDGNIEACKRKLYTIVSTLPCPACRRHATIAIEDNNVMSSDDLNYIYYFFIRLFNNLAFDPKYAIDVSKVKPL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT903340
EMBL· GenBank· DDBJ
QNP12928.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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