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A0A7G9LE22 · A0A7G9LE22_9FLAO

  • Protein
    Glyceraldehyde-3-phosphate dehydrogenase
  • Gene
    gap
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

Catalytic activity

Features

Showing features for binding site, active site, site.

133350100150200250300
Type
IDPosition(s)Description
Binding site11-12NAD+ (UniProtKB | ChEBI)
Binding site33NAD+ (UniProtKB | ChEBI)
Binding site77NAD+ (UniProtKB | ChEBI)
Binding site119NAD+ (UniProtKB | ChEBI)
Binding site149-151D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Active site150Nucleophile
Site177Activates thiol group during catalysis
Binding site180D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site209-210D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site232D-glyceraldehyde 3-phosphate (UniProtKB | ChEBI)
Binding site315NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Processglucose metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glyceraldehyde-3-phosphate dehydrogenase
  • EC number

Gene names

    • Name
      gap
    • ORF names
      H9W90_07105

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • L12M9
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae

Accessions

  • Primary accession
    A0A7G9LE22

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-150Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    35,758
  • Last updated
    2021-02-10 v1
  • MD5 Checksum
    CA300677E56CF2C3F9EE674CE6E871FD
MIKVGINGFGRIGRLAFRSTVNRPGVQVVAINDLLDVDYLAYMLKYDSVHGKFDGTVDVKDGKLVVNGNEIRITAERDPANLKWDEVDAEYVIESTGFFLTEETAGKHLEAGAKKVVLSAPSKDHTPMFVMGVNNTELKADQKIFSNASCTTNCLSPIAKVLNDNWGISEGLMTTVHAATATQKTVDGPSMKDWRGGRSAIGNVIPSSTGAAKAVGKVIPALNGKLTGMAFRIPTMDVSVVDLTVKLEKPATYAEICAAMKAASESGPMKGVLGYTEDMVVSQDFVGDTRTSIFDAKAGIALNDNFVKVVSWYDNEIGYSTKIVDLIEYAATL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP060695
EMBL· GenBank· DDBJ
QNM86871.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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