A0A7G9L980 · A0A7G9L980_9FLAO
- ProteinGDP-L-fucose synthase
- Genefcl
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids350 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Catalytic activity
- GDP-beta-L-fucose + NADP+ = GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
Pathway
Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11-17 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 106-109 | NADP+ (UniProtKB | ChEBI) | |||
Site | 108 | Important for catalytic activity | |||
Site | 110 | Important for catalytic activity | |||
Active site | 137 | Proton donor/acceptor | |||
Binding site | 141 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 164-167 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 180 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 188 | substrate | |||
Binding site | 232 | substrate | |||
Binding site | 239 | substrate | |||
Binding site | 310 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | GDP-L-fucose synthase activity | |
Molecular Function | isomerase activity | |
Molecular Function | NADP+ binding | |
Biological Process | 'de novo' GDP-L-fucose biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGDP-L-fucose synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae
Accessions
- Primary accessionA0A7G9L980
Proteomes
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length350
- Mass (Da)39,521
- Last updated2021-02-10 v1
- MD5 Checksum55DBC5869159C00330744ECDAA8A8972
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP060695 EMBL· GenBank· DDBJ | QNM85179.1 EMBL· GenBank· DDBJ | Genomic DNA |