Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A7G9L980 · A0A7G9L980_9FLAO

  • Protein
    GDP-L-fucose synthase
  • Gene
    fcl
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

Catalytic activity

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.

Features

Showing features for binding site, site, active site.

135050100150200250300350
Type
IDPosition(s)Description
Binding site11-17NADP+ (UniProtKB | ChEBI)
Binding site106-109NADP+ (UniProtKB | ChEBI)
Site108Important for catalytic activity
Site110Important for catalytic activity
Active site137Proton donor/acceptor
Binding site141NADP+ (UniProtKB | ChEBI)
Binding site164-167NADP+ (UniProtKB | ChEBI)
Binding site180NADP+ (UniProtKB | ChEBI)
Binding site188substrate
Binding site232substrate
Binding site239substrate
Binding site310substrate

GO annotations

AspectTerm
Molecular FunctionGDP-L-fucose synthase activity
Molecular Functionisomerase activity
Molecular FunctionNADP+ binding
Biological Process'de novo' GDP-L-fucose biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GDP-L-fucose synthase
  • EC number
  • Alternative names
    • GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase

Gene names

    • Name
      fcl
    • ORF names
      H9W90_13430

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • L12M9
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae

Accessions

  • Primary accession
    A0A7G9L980

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-261NAD-dependent epimerase/dehydratase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    350
  • Mass (Da)
    39,521
  • Last updated
    2021-02-10 v1
  • MD5 Checksum
    55DBC5869159C00330744ECDAA8A8972
MNKNDKIFLAGHRGLVGSAILKNLKERGFLNIITKTHKELDLSNQQATADFFAKEKPDYVFLAAAKVGGIVANNTYRADFIYHNLMIQNNVVHESYINGVKKLLFLGSTCIYPKNAAQPIQENSLLTDVLEYTNEPYAIAKIAGIKLCESYNLQYNTNFISVMPTNLYGPNDNFDLEKSHVLPALIKKIHLAKLLEEGNNEAVVKELKVDNFEEAEIILSKFGISSKAIEIWGTGKPMREFLWSEDMADACVHIMQNVDFTDLIKDKKEVRNTHINIGTGNDIAIKDLANLIKEVVGFKGDFIFNSDKPDGTMRKVTDVSKLKKLGWQHSVKLEKGIQMMYDWYLKQPNG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP060695
EMBL· GenBank· DDBJ
QNM85179.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help