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A0A7G9L6H0 · A0A7G9L6H0_9FLAO

  • Protein
    DNA-directed RNA polymerase subunit alpha
  • Gene
    rpoA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionprotein dimerization activity
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit alpha
  • EC number
  • Short names
    RNAP subunit alpha
  • Alternative names
    • RNA polymerase subunit alpha
    • Transcriptase subunit alpha

Gene names

    • Name
      rpoA
    • ORF names
      H9W90_08340

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • L12M9
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae

Accessions

  • Primary accession
    A0A7G9L6H0

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-231Alpha N-terminal domain (alpha-NTD)
Domain21-231DNA-directed RNA polymerase RpoA/D/Rpb3-type
Region253-330Alpha C-terminal domain (alpha-CTD)

Domain

The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

Sequence similarities

Belongs to the RNA polymerase alpha chain family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    330
  • Mass (Da)
    37,254
  • Last updated
    2021-02-10 v1
  • MD5 Checksum
    AAF2ED9C577D523DE3193E9090FF21AD
MAILNFQKPDKVIMIESTDFSGRFEFRPLEPGFGLTVGNALRRVLLSSLEGFAITSLRVDGVEHEFSTVSGIVEDVTEIILNLKQVRFKKQIEDTDRETVSVSVSGQEQFTAGDLQKFISGFQVLNPDLVICNMDKSVKLNAEITIEKGRGFVPAEENKKASAPIGTIFTDSIYTPIKNVKYAIENFRVEQKTDYEKLVFDIDTDGSINPKDALTEAAKILIHHFMLFSDERITLEADEIAQTETYDEESLHMRQLLKTRLIDMDLSVRALNCLKAAEVDTLGDLVSFNKSDLMKFRNFGKKSLTELEELVIVKGLNFGMDLTKYKLDRD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP060695
EMBL· GenBank· DDBJ
QNM84219.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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