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A0A7G9L6G8 · A0A7G9L6G8_9FLAO

  • Protein
    Carbamoyl phosphate synthase small chain
  • Gene
    carA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site51L-glutamine (UniProtKB | ChEBI)
Binding site229L-glutamine (UniProtKB | ChEBI)
Binding site231L-glutamine (UniProtKB | ChEBI)
Active site257Nucleophile
Binding site258L-glutamine (UniProtKB | ChEBI)
Binding site261L-glutamine (UniProtKB | ChEBI)
Binding site299L-glutamine (UniProtKB | ChEBI)
Binding site301L-glutamine (UniProtKB | ChEBI)
Binding site302L-glutamine (UniProtKB | ChEBI)
Active site343
Active site345

GO annotations

AspectTerm
Cellular Componentcarbamoyl-phosphate synthase complex
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processarginine biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyl phosphate synthase small chain
  • EC number
  • Alternative names
    • Carbamoyl phosphate synthetase glutamine chain

Gene names

    • Name
      carA
    • ORF names
      H9W90_08330

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • L12M9
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae

Accessions

  • Primary accession
    A0A7G9L6G8

Proteomes

Subcellular Location

Interaction

Subunit

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-180CPSase
Domain7-137Carbamoyl-phosphate synthase small subunit N-terminal

Sequence similarities

Belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    373
  • Mass (Da)
    41,316
  • Last updated
    2021-02-10 v1
  • MD5 Checksum
    A1C2F8E8B22BA2022F048BE01C70FD44
MKYQTRKKALVLLADGTIFYGKSVGIEGTSTGEICFNTGMTGYQEIFTDPSYFGQLMVATNAHIGNYGVNDNEVESDGIKISGLICRNFSFTHSRVDSDGNLKDWFTKHNLVAISDVDTRALVAYIRDNGAMNAIISTEIDNIEALKDQLAKVPSMEGLELASKVSTKEPYFVGDEKAEIKISALDIGIKKNILRNLAKRGAYIKVFPYNSSFEDLSNFNPDGYFISNGPGDPEPLKEAQEVAKEIIKRNLPLFGICLGHQVIALSQNISTYKMHNGHRGINHPVKNLLTGKGEITSQNHGFAINREEAEANENIEITHVHLNDHTVAGIRIKDKNTFSVQYHPEASPGPHDSEYLFDEFIKNIKNSKKVSVS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP060695
EMBL· GenBank· DDBJ
QNM84217.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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