A0A7G6KLV7 · A0A7G6KLV7_CHRBR
- ProteinAngiotensin-converting enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids802 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- angiotensin I + H2O = angiotensin-(1-9) + L-leucineThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 374 | Proton acceptor 1 | ||||
Sequence: E | ||||||
Active site | 504 | Proton donor 1 | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | extracellular space | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metallopeptidase activity | |
Molecular Function | peptidyl-dipeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAngiotensin-converting enzyme
- EC number
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Chrysocyon
Accessions
- Primary accessionA0A7G6KLV7
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 738-762 | Helical | ||||
Sequence: IWLIVFGVVMGVVVVGIVLLIFSGI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MSGSSWLLLSLAALTAA | ||||||
Chain | PRO_5028991449 | 18-802 | Angiotensin-converting enzyme | |||
Sequence: QSTEDLVKTFLEKFNYEAEELSYQSSLASWNYNINITDENVQKMNNAGAKWSAFYEEQSKLAKTYPLEEIQDSTVKRQLRALQHSGSSVLSADKNQRLNTILNSMSTIYSTGKACNPSNPQECLLLEPGLDDIMENSKDYNERLWAWEGWRSEVGKQLRPLYEEYVALKNEMARANNYEDYGDYWRGDYEEEWENGYNYSRNQLIDDVEHTFTQIMPLYQHLHAYVRTKLMDTYPSYISPTGCLPAHLLGDMWGRFWTNLYPLTVPFGQKPNIDVTNAMVNQSWDARKIFKEAEKFFVSVGLPNMTQEFWENSMLTEPSDSRKVVCHPTAWDLGKGDFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPNHLKNIGLLPPSFFEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKTWWEMKRNIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRTIYQFQFQEALCQIAKHEGPLHKCDISNSSEAGQKLLEMLKLGKSKPWTYALEIVVGAKNMDVRPLLNYFEPLFTWLKEQNRNSFVGWNTDWSPYADQSIKVRISLKSALGEKAYEWNNNEMYLFRSSIAYAMRQYFSEVKNQTIPFVEDNVWVSDLKPRISFNFFVTSPGNVSDIIPRTEVEEAIRRSRINDVFRLDDNSLEFLGIQPTLGPPYEPPVTIWLIVFGVVMGVVVVGIVLLIFSGIRNRRKNDQARGEENPYASVDLSKGENNPGFQNVDDAQTSF | ||||||
Glycosylation | 52 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 132↔140 | |||||
Sequence: CNPSNPQEC | ||||||
Disulfide bond | 343↔360 | |||||
Sequence: CHPTAWDLGKGDFRIKMC | ||||||
Disulfide bond | 529↔541 | |||||
Sequence: CQIAKHEGPLHKC | ||||||
Glycosylation | 577 | N-linked (GlcNAc...) asparagine; partial | ||||
Sequence: N |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 613-802 | Collectrin-like | ||||
Sequence: ADQSIKVRISLKSALGEKAYEWNNNEMYLFRSSIAYAMRQYFSEVKNQTIPFVEDNVWVSDLKPRISFNFFVTSPGNVSDIIPRTEVEEAIRRSRINDVFRLDDNSLEFLGIQPTLGPPYEPPVTIWLIVFGVVMGVVVVGIVLLIFSGIRNRRKNDQARGEENPYASVDLSKGENNPGFQNVDDAQTSF | ||||||
Region | 769-802 | Disordered | ||||
Sequence: DQARGEENPYASVDLSKGENNPGFQNVDDAQTSF | ||||||
Compositional bias | 782-802 | Polar residues | ||||
Sequence: DLSKGENNPGFQNVDDAQTSF |
Sequence similarities
Belongs to the peptidase M2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length802
- Mass (Da)92,552
- Last updated2021-02-10 v1
- Checksum438569B1CA7690EC
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 782-802 | Polar residues | ||||
Sequence: DLSKGENNPGFQNVDDAQTSF | ||||||
Non-terminal residue | 802 | |||||
Sequence: F |