A0A7G2SIH1 · A0A7G2SIH1_ACISP

  • Protein
    Fatty acid oxidation complex subunit alpha
  • Gene
    fadB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site120Important for catalytic activity
Site140Important for catalytic activity
Binding site298substrate
Binding site326NAD+ (UniProtKB | ChEBI)
Binding site345NAD+ (UniProtKB | ChEBI)
Binding site402-404NAD+ (UniProtKB | ChEBI)
Binding site409NAD+ (UniProtKB | ChEBI)
Binding site431NAD+ (UniProtKB | ChEBI)
Active site452For 3-hydroxyacyl-CoA dehydrogenase activity
Binding site455NAD+ (UniProtKB | ChEBI)
Binding site502substrate

GO annotations

AspectTerm
Cellular Componentfatty acid beta-oxidation multienzyme complex
Molecular Function3-hydroxyacyl-CoA dehydrogenase activity
Molecular Function3-hydroxybutyryl-CoA epimerase activity
Molecular Functiondelta(3)-delta(2)-enoyl-CoA isomerase activity
Molecular Functionenoyl-CoA hydratase activity
Molecular FunctionNAD+ binding
Biological Processfatty acid beta-oxidation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fatty acid oxidation complex subunit alpha

Including 2 domains:

  • Recommended name
    Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase
  • EC number
  • Recommended name
    3-hydroxyacyl-CoA dehydrogenase
  • EC number

Gene names

    • Name
      fadB
    • ORF names
      CL490_14975

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A7G2SIH1

Proteomes

Interaction

Subunit

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-190Enoyl-CoA hydratase/isomerase
Region313-7173-hydroxyacyl-CoA dehydrogenase
Domain318-4963-hydroxyacyl-CoA dehydrogenase NAD binding
Domain498-5933-hydroxyacyl-CoA dehydrogenase C-terminal
Domain629-7133-hydroxyacyl-CoA dehydrogenase C-terminal

Sequence similarities

In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    717
  • Mass (Da)
    77,985
  • Last updated
    2021-02-10 v1
  • Checksum
    C0981AB69CA14483
MIHAGNAITVQMLSDGIAEFRFDLQGESVNKFNRATIEDFQAAIEAVKNHPEVKGLIVTSAKSTFIVGADITEFGQNFAQGEKAIVEWALPVHDIFNSFEDLDIPKVAAINGMALGGGFEMCLVCDYRVMSDQAQVGLPEIKLGIFPGFGGTVRLSRLIGIDNAVEWIAMAAPKKPAAALKDGAVDAVVSADKLQEAAIDLVKQALAGRVDWKAKRQEKLNPVKLNPLEQMMAFNTAKGAVLAKANPAQYPAPKLMLDSLQAGASLGRDEALKVETEGFAKAAITPQAEALIGLFLNDQIIKKTSKKHEKGAHPVNQAAVLGAGIMGGGIAYQAASKGTPIIMKDIGNPQLALGMQEANGLLTKQVERKKLTPAKMGETLARIRPTLSYDEFKEVDIVIEAVTENPKIKEAVLADTEAKVRDNTIIASNTSTISITRLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEQTSEEAVATTVVLAQKMGKTPIVVNDCPGFLVNRVLFPYFGAFDLLLKDGADFQQIDKVMEKFGWPMGPAYLMDVVGIDTGVHGAEVMAEGFPDRMKPDYKGSIQTMYEAKRLGQKNDVGFYKYELDKKGKKAKTVDSTAYEVIAPVVTSEKREFDAQEIIDRMMLALCNETVRCLEDNIVATPAEADMAMIMGIGFPPFRGGPCRYIDQTGVAEYVALCNKYAHLGKAYEAPQLLRDMAENNKKFYG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NZLS01000136
EMBL· GenBank· DDBJ
MAK31744.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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