A0A7G2CB30 · A0A7G2CB30_9TRYP
- ProteintRNA wybutosine-synthesizing protein 4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1082 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Catalytic activity
- 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine37 in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H+ + S-adenosyl-L-homocysteine + wybutosine37 in tRNA(Phe)
RHEA-COMP:11844 + CHEBI:16526 + CHEBI:59789 = 2 CHEBI:15378 + CHEBI:57856 + RHEA-COMP:11847 CHEBI:73544 Position: 37
Pathway
tRNA modification; wybutosine-tRNA(Phe) biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | protein C-terminal leucine carboxyl O-methyltransferase activity | |
Molecular Function | tRNA methyltransferase activity | |
Biological Process | tRNA methylation | |
Biological Process | wybutosine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametRNA wybutosine-synthesizing protein 4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Strigomonadinae > Angomonas
Accessions
- Primary accessionA0A7G2CB30
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MENTPPETISKRKEKKAKRV | ||||||
Domain | 869-1021 | JmjC | ||||
Sequence: DFSALGKDLVLPPGVDSFVGPRLHQSCLRINTAPLQLWTHYDTMDNVLLQVTGRKRVVLFPPSQYNNLYMSGSSSPVIDLDHPDLVQYPRMIEALKHSTEVTLEPGDMLYFPANWFHHITTLQGDTPLVISVNAFFHHFESPDYDAKDLYGNK |
Sequence similarities
Belongs to the methyltransferase superfamily. LCMT family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,082
- Mass (Da)119,989
- Last updated2021-02-10 v1
- Checksum9F351E20EBD22F2C
Keywords
- Technical term