A0A7G2CB30 · A0A7G2CB30_9TRYP

  • Protein
    tRNA wybutosine-synthesizing protein 4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.

Catalytic activity

Pathway

tRNA modification; wybutosine-tRNA(Phe) biosynthesis.

GO annotations

AspectTerm
Molecular Functionprotein C-terminal leucine carboxyl O-methyltransferase activity
Molecular FunctiontRNA methyltransferase activity
Biological ProcesstRNA methylation
Biological Processwybutosine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA wybutosine-synthesizing protein 4
  • EC number
  • Alternative names
    • Leucine carboxyl methyltransferase 2
    • tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase
    • tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase

Gene names

    • ORF names
      ADEAN_000421200

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Crithidia deanei Carvalho (ATCC PRA-265)
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Strigomonadinae > Angomonas

Accessions

  • Primary accession
    A0A7G2CB30

Proteomes

Organism-specific databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-20Disordered
Domain869-1021JmjC

Sequence similarities

Belongs to the methyltransferase superfamily. LCMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,082
  • Mass (Da)
    119,989
  • Last updated
    2021-02-10 v1
  • Checksum
    9F351E20EBD22F2C
MENTPPETISKRKEKKAKRVNKKISLPGSVDVRVQHTNDDSVVSKRSAVSCGYVADPFLRLFVRKPTRRSPLVNRGYYLRMVVMTDLITKCIEKCLAMPSNSSHSVQVISLGAGYDTFALRYLLGDQAHEHSGPVHFYDVDFPEVMQSKAALMSAAPPGTFPVDWSIQYENAANPVSSASYSAVGVDLRRSEEVLLESLQNVSSQFSSSNLTIVYAECVMQYMPAEKAASLIQTLATHFPNLYFFAYDQLHPSDSFGKVMTGALQQKQSPLLSVATVPGGTEMIARAKEGGMRHVRFANFYDLSRQYIDESETERERVDRLEAFDEFEEWGEMCEHYGITFATTAKEPMQLGDCFTGCEAKTPGLPSNKQVSVHHWPSGRFGFAGWGNGNVHREELANGDVLLVSFGGFDVIKQHQRVNTFRVHSLREGEVRTVLQENEHTPPGLVFHSFDRLGPFTYVVAGGRTSPTSVNGDVFIFKLHMTATQEVSINSTLSVTCTRIASGSSLTERYRHASVVIGDNKLLLVGGKNSSGQCVTEACLLEIQEGQAVTVQPITLEGLPPLFSAAAAKLSDGRILLCGGVNCAFKAYDTMWYLDIGKGKVDVVQQCAALERFSHTATTVQLDGEEFVLIVGGTSTRPKEVVNLDPIFYNVKSGQMEVPHVEGELPSWSRHACVELASGVIGVVGGGYTCFSFATFTAKPALLYLSPDAEQNMKRCLVASRESLPNGTDPTVGANIQRLSNFLCTERERVRELTFSPEIFRNVATKAEKPCVFRNVNMGSCTTKWADPAYLKSVEGETVVSVHVAEGSHLLDFVRKNFTFRHVQFSELVDHLVSSNAYHREHGEVPQETWYYRSVSTHMKTERSDVWKDFSALGKDLVLPPGVDSFVGPRLHQSCLRINTAPLQLWTHYDTMDNVLLQVTGRKRVVLFPPSQYNNLYMSGSSSPVIDLDHPDLVQYPRMIEALKHSTEVTLEPGDMLYFPANWFHHITTLQGDTPLVISVNAFFHHFESPDYDAKDLYGNKDLPAVTQLRESILNQTRAAMASAQVNPGCALPVEYKEFALRQIIHDLESLANDITAGAQTL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR877151
EMBL· GenBank· DDBJ
CAD2216739.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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