A0A7G1HHN6 · A0A7G1HHN6_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3341 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus
Accessions
- Primary accessionA0A7G1HHN6
Subcellular Location
UniProt Annotation
GO Annotation
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 71-93 | Helical | ||||
Sequence: LQLDIGAAVLCLALAVGSLGQQL | ||||||
Transmembrane | 113-133 | Helical | ||||
Sequence: YGPVSFFCLAFMFGLALSETL | ||||||
Transmembrane | 669-696 | Helical | ||||
Sequence: WFLPVVLIVLSMVFLGRGVTLIIVVVIA | ||||||
Transmembrane | 1109-1127 | Helical | ||||
Sequence: GFDRSVLNLLCLAIALQLI | ||||||
Transmembrane | 1139-1166 | Helical | ||||
Sequence: LILTTVAMLTFGLPNIFSSVGLSAWVFL | ||||||
Transmembrane | 1178-1199 | Helical | ||||
Sequence: VMNLWIILQTGSSAVILLGFMV | ||||||
Transmembrane | 1205-1225 | Helical | ||||
Sequence: IVLGHHHLMALICLQFLFWVV | ||||||
Transmembrane | 1232-1251 | Helical | ||||
Sequence: FSVFLEAVAAIVLIGAYRGM | ||||||
Transmembrane | 1308-1324 | Helical | ||||
Sequence: AWFWTISCASAGAIWAA | ||||||
Transmembrane | 1330-1347 | Helical | ||||
Sequence: PSAAAVLALITIIVFLYM | ||||||
Transmembrane | 1406-1428 | Helical | ||||
Sequence: VIILIGCALTSASLFVGALYTIL | ||||||
Transmembrane | 2088-2113 | Helical | ||||
Sequence: MAFMLGCAIAVALLMFIWVFTCLMSY | ||||||
Transmembrane | 2134-2163 | Helical | ||||
Sequence: FFLTSPGVLHYFGVPLGFCVIIFLAMFIVY | ||||||
Transmembrane | 2183-2202 | Helical | ||||
Sequence: WVILGSCVMCSVLAWEMRLF | ||||||
Transmembrane | 2296-2325 | Helical | ||||
Sequence: VIPSCFVITMTVGLPSVVIGAGAAALFMFI | ||||||
Transmembrane | 2366-2382 | Helical | ||||
Sequence: AIMYAYCMALSLLWVFC | ||||||
Transmembrane | 2416-2436 | Helical | ||||
Sequence: FGSMLSAIGLIDMNFLFYKFL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Forms a heterodimer with serine protease NS3. May form homooligomers.
Forms heterodimers with envelope protein E in the endoplasmic reticulum and Golgi.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-54 | Disordered | ||||
Sequence: MNRMLLKKGPLAQTSGRPSTRPPDPAEKRVKRAVGNNTSRNQRPPTRGATPSSL | ||||||
Compositional bias | 35-54 | Polar residues | ||||
Sequence: GNNTSRNQRPPTRGATPSSL | ||||||
Domain | 1452-1630 | Peptidase S7 | ||||
Sequence: SDDLLGFGGESDQKIETSFGDLPNGIYRINVRSFMENRQRGVGVAKNGVFHTLMHVTRGEPLQWRGKLVSLHSGSALRDVVSYGGPWQLESPTVAEEISLMACKPDKTVEYHKYKPGVIKLDNENMMFISVDFGKGSSGSPFFVNGEVVGFYGFGFYVNGVYRSIVAGGRPGDITPNEV | ||||||
Domain | 1627-1780 | Helicase ATP-binding | ||||
Sequence: PNEVTDSTRKFITWHPGKGKTRRVIVSEVKTNFDAGLRTIVLTPTRVVMAEVVEALGQAGITSDRNLMYCRRNLVTVACHATFTKFVLSHGVKKIGVALIIMDECHFMDPMSIAARGVMEHLHEKGTKLMYLSATPPGHSPDGGSNFPIHDQAI | ||||||
Domain | 2454-2706 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: ALEKSTTIGLGVKWKFMLNALDKDAFEGYKVRGVNETGKGDYVSRGGLKLDEIIRKYQWTPMGHVVDLGCGRGGWSQRVAMEETVTSVHGFTIGGNDKENPQRFVTRGYNLTNLKPGVDVYKLEPKRCDTIMCDIGESDPNLIKERTRTLKVLQLLETWLSVNPEAQFVCKVLSPYSLEVLRKVESLQQRYRGKLVRLAHSRNSTAEMYYISGNRSNAVRDAYMTLAALTGRFSRHIDSVFLPEPTLPRGTRA | ||||||
Domain | 2970-3117 | RdRp catalytic | ||||
Sequence: KYLFADDIAGWDTKVSSEDLEDEETLLTELTVNPFHRALIAATMKLAYRNIVAMFPRTHTRYGSGTVMDVVGRTDQRGSGQVVTYALNTITNGKVQVARALESEGLLYADSQVIDRWLDKNLEDVLSCMTIAGDDVVVSTMNRSFASS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,341
- Mass (Da)373,097
- Last updated2021-02-10 v1
- Checksum44A526F69C54282F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 35-54 | Polar residues | ||||
Sequence: GNNTSRNQRPPTRGATPSSL |