A0A7E6E237 · A0A7E6E237_9CHIR
- ProteinDelta(14)-sterol reductase TM7SF2
- GeneTM7SF2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids352 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + H+ + NADPH
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + H+ + NADPH = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + H+ + NADPH = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nuclear inner membrane | |
Molecular Function | delta14-sterol reductase activity | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase TM7SF2
- EC number
- Short namesDelta-14-SR
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Phyllostomidae > Phyllostominae > Phyllostomus
Accessions
- Primary accessionA0A7E6E237
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 12-36 | Helical | ||||
Sequence: FGGPLGAAALMLLLPATMFHLLLAA | ||||||
Transmembrane | 56-78 | Helical | ||||
Sequence: LWSPRALLLWFTWLGLQVAFYLL | ||||||
Transmembrane | 185-203 | Helical | ||||
Sequence: THDGFGFMLAFGDLVWVPF | ||||||
Transmembrane | 223-241 | Helical | ||||
Sequence: MASALCLMNAVGFYIFRAA | ||||||
Transmembrane | 289-310 | Helical | ||||
Sequence: LIMALAWSLPCGVSHLLPYFYL |
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length352
- Mass (Da)40,146
- Last updated2021-02-10 v1
- Checksum0B85FE72C8FF4B01
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6J2M1K8 | A0A6J2M1K8_9CHIR | TM7SF2 | 417 | ||
A0A7E6E3J0 | A0A7E6E3J0_9CHIR | TM7SF2 | 409 |
Keywords
- Technical term