A0A7E6E237 · A0A7E6E237_9CHIR

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear inner membrane
Molecular Functiondelta14-sterol reductase activity
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase TM7SF2
  • EC number
  • Short names
    Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Sterol C14-reductase
    • Transmembrane 7 superfamily member 2

Gene names

    • Name
      TM7SF2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Phyllostomidae > Phyllostominae > Phyllostomus

Accessions

  • Primary accession
    A0A7E6E237

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-36Helical
Transmembrane56-78Helical
Transmembrane185-203Helical
Transmembrane223-241Helical
Transmembrane289-310Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    352
  • Mass (Da)
    40,146
  • Last updated
    2021-02-10 v1
  • Checksum
    0B85FE72C8FF4B01
MAPQGSRAPLEFGGPLGAAALMLLLPATMFHLLLAARSGPARLLDLPPYLPRLEALWSPRALLLWFTWLGLQVAFYLLPARKMAEGQELKDKSRLRYPINGNPIYDFFLGRELNPRIGSFDFKYFCELRPGLIAWVLINLALLVQEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDLVWVPFTYSLQAQFLLYHPQPLELPMASALCLMNAVGFYIFRAANSQKNTFRKNPSDPRVADLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDEQQCLQKYGLAWHEYCRRVPYRIVPYVY

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A6J2M1K8A0A6J2M1K8_9CHIRTM7SF2417
A0A7E6E3J0A0A7E6E3J0_9CHIRTM7SF2409

Keywords

Sequence databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp