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A0A7D9H412 · A0A7D9H412_9GAMM

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site322-333ATP (UniProtKB | ChEBI)
Binding site694Mg2+ (UniProtKB | ChEBI)
Binding site733Mg2+ (UniProtKB | ChEBI)
Binding site737Mg2+ (UniProtKB | ChEBI)
Binding site901Mg2+ (UniProtKB | ChEBI)
Active site1149Nucleophile
Active site1270
Active site1272

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • ORF names
      JTBM06_V1_130011

Organism names

  • Taxonomic identifier
  • Strain
    • Gfbio:sag-sample-m06:053724c1-46a9-4a36-b237-ea2bf867836b
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Woeseiales > Woeseiaceae > environmental samples

Accessions

  • Primary accession
    A0A7D9H412

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain51-165Phosphoribosylformylglycinamidine synthase N-terminal
Domain188-235Phosphoribosylformylglycinamidine synthase linker
Domain447-604PurM-like C-terminal
Domain663-822FGAR-AT PurM-N-like
Domain853-981PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,305
  • Mass (Da)
    140,969
  • Last updated
    2020-12-02 v1
  • MD5 Checksum
    4AD6B3C4DBDC30A9A7EAD639D5555DEB
MSTPATDLPVETANSILELAGQSALSTFRLRKLLVQLQLIDTRVSGLRARFTYFVSVSEAPPPEQRQHLDALLLSNDEIEVFPDSAQLIYTGPRPGTISPWSSKATDIARACRLGSVVRIERGICYAIECKDTLSSAELPRLGASLFDRMTECQFASGAEAAVLFAEHPPAALATIPLLEDGTDALFRADRELGLALSDDEIEYLAKNYRQLDRNPTDAELMMFAQANSEHCRHKIFCADWIIDGVVQDQKLFDMIKSTTEASPDGVISAYSDNAAVMAGWDGKRLGPRPADRQFGYSDEPIHILMKVETHNHPTAISPFPGAATGSGGEIRDEGATGLGARPKAGLTGFTVSHLRIPDFAQPWEQPFGHSDRMATPLEIMLDGPIGGAAFNNEFGRPNLLGYFRTYESHVPGLPDGEIRGYHKPIMIAGGVGNVRDEHALKIEVPVGAAIIVLGGPAMLIGLGGGAASSLGSGTSSEDLDFASVQRGNPEMERRAQEVIDQCTSMGADNPILLIHDVGAGGLSNAVPEAVDHSKHGAEVELRDVPNAEPGMSPMNIWCNEAQERYVLLIGPERIAEFERICARERCPFAVIGKLTANRQLIVTDRDFDNRVVDMPMEMLFGKPPKMTRDVTRIETPITDMDLDGIELEEAIFRVLRFPAVADKSFLIHIGDRTVGGLSVRDQLIGPWQVAVSDVAITASGFASQTGEAMAMGERTPLAALNAPASGRIAVGEAVTNIAAAAIDDIKDIKLSANWMAAAGHPGEDARLFDTVKAVGAELCRDLGIAIPVGKDSLSMRAHWMDEGGERQVVAPVSLIVSAFAPVTDIRRHLTPQLRHIDERSQLLLLDIGEGANRLGGSCLAQAFQRHGGVTPDLDFPQHLKSFFSAIQSLNKRGLILAYHDRADGGLLATVAEMMFAGRLGASLKLAGSAHDMLAQLFSEELGGVIQVASSKLAEAHAVLEENSTGWVDIGAVEPDDQLSIYNDDELVLRLDRTSLQRVWSETSYRLQSLRDNPQTAKEEFDRLLDTEDPGLHVKLSFDPADDIVAPLVGGLQPRVAILREQGVNSQMEMAAAFMRAGFTTVDVHMHDLINGEDSLGNYQGIAACGGFSFGDVLGAGGGWAKSILYQSVLRDEFAAFFERGDSFALGVCNGCQMLSHLRELIPGAADWPAFRRNKSEQFEARLSLVEVVDSSSLFLAGMAGSTMPIATSHGEGQAIFADAEAQARARVALRYIDNYGAIAREYPANPNGSAAGICGLVSDDGRVTVMMPHPERVARTTQNSWHPDNWGDDGPWMRIFRNARVAIS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR633967
EMBL· GenBank· DDBJ
VUX55834.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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