A0A7D9D1K4 · A0A7D9D1K4_9GAMM

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

127920406080100120140160180200220240260
Type
IDPosition(s)Description
Binding site22-24shikimate (UniProtKB | ChEBI)
Binding site69shikimate (UniProtKB | ChEBI)
Active site73Proton acceptor
Binding site85NADP+ (UniProtKB | ChEBI)
Binding site94shikimate (UniProtKB | ChEBI)
Binding site109shikimate (UniProtKB | ChEBI)
Binding site134-138NADP+ (UniProtKB | ChEBI)
Binding site158-163NADP+ (UniProtKB | ChEBI)
Binding site223NADP+ (UniProtKB | ChEBI)
Binding site225shikimate (UniProtKB | ChEBI)
Binding site247NADP+ (UniProtKB | ChEBI)
Binding site254shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      JTBM06_V1_50039

Organism names

  • Taxonomic identifier
  • Strain
    • Gfbio:sag-sample-m06:053724c1-46a9-4a36-b237-ea2bf867836b
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Woeseiales > Woeseiaceae > environmental samples

Accessions

  • Primary accession
    A0A7D9D1K4

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-96Shikimate dehydrogenase substrate binding N-terminal
Domain124-200Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Domain247-276SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    279
  • Mass (Da)
    30,238
  • Last updated
    2020-12-02 v1
  • Checksum
    6B462C2DDDCA4FFF
MTNVVDNDVDRYGVMGYPVSHSRSPVIHRLFAQQTGQDLQYELLEVPPDKLETAIKQFERTGGKGLNITLPHKSEVTKLVDRMSERASNAGAINTLVFRDGEIFGDNTDGVGLLRDLELNLGLQLKDTNILILGAGGATRGIVSPLLNANPASVMIANRTISKAEALAEHYSSEGPVGACRFQDVRSPPVYDLVINATSAGVKGETPPYPEAAIADHTICYDLSYSMRTTPFSSWAKEHGAARSVMGWGMLIEQAAESFQLWRGVQPDTAVVLKQVSVV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LR633967
EMBL· GenBank· DDBJ
VUX55600.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help