A0A7D7Y6L5 · A0A7D7Y6L5_9MOLU
- Protein1-deoxy-D-xylulose 5-phosphate reductoisomerase
- Genedxr
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids368 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Catalytic activity
- 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+This reaction proceeds in the backward direction.
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 9 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 10 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 11 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 12 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 35 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 106 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 107 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 108 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 132 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 133 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 134 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 134 | Mn2+ (UniProtKB | ChEBI) | |||
Binding site | 158 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 181 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 187 | NADPH (UniProtKB | ChEBI) | |||
Binding site | 194 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 199 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 200 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 203 | 1-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI) | |||
Binding site | 203 | Mn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity | |
Molecular Function | isomerase activity | |
Molecular Function | manganese ion binding | |
Molecular Function | NADPH binding | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-deoxy-D-xylulose 5-phosphate reductoisomerase
- EC number
- Short namesDXP reductoisomerase
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Mycoplasmatota > Mollicutes > Mycoplasmataceae > Mycoplasma
Accessions
- Primary accessionA0A7D7Y6L5
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-114 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal | |||
Domain | 128-211 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal | |||
Domain | 243-349 | DXP reductoisomerase C-terminal | |||
Sequence similarities
Belongs to the DXR family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)42,307
- Last updated2020-12-02 v1
- Checksum42E4541D1A2A3E79
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP059674 EMBL· GenBank· DDBJ | QMT98616.1 EMBL· GenBank· DDBJ | Genomic DNA |