A0A7D7Y6L5 · A0A7D7Y6L5_9MOLU

  • Protein
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • Gene
    dxr
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site9NADPH (UniProtKB | ChEBI)
Binding site10NADPH (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site35NADPH (UniProtKB | ChEBI)
Binding site106NADPH (UniProtKB | ChEBI)
Binding site1071-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site108NADPH (UniProtKB | ChEBI)
Binding site132Mn2+ (UniProtKB | ChEBI)
Binding site1331-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1341-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site134Mn2+ (UniProtKB | ChEBI)
Binding site1581-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1811-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site187NADPH (UniProtKB | ChEBI)
Binding site1941-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site1991-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2001-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site2031-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site203Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Molecular Functionisomerase activity
Molecular Functionmanganese ion binding
Molecular FunctionNADPH binding
Biological Processisopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • EC number
  • Short names
    DXP reductoisomerase
  • Alternative names
    • 1-deoxyxylulose-5-phosphate reductoisomerase
    • 2-C-methyl-D-erythritol 4-phosphate synthase

Gene names

    • Name
      dxr
    • ORF names
      H3143_00470

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 56A97T
  • Taxonomic lineage
    Bacteria > Mycoplasmatota > Mollicutes > Mycoplasmataceae > Mycoplasma

Accessions

  • Primary accession
    A0A7D7Y6L5

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-1141-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Domain128-2111-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
Domain243-349DXP reductoisomerase C-terminal

Sequence similarities

Belongs to the DXR family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    368
  • Mass (Da)
    42,307
  • Last updated
    2020-12-02 v1
  • Checksum
    42E4541D1A2A3E79
MKVLVLGATGSIGKQAIDVICQLKYQLVGFSYYQNHDEANNILKQLNPNYVLCHSDPKYNKNIKGSLIELIDKSKPKVIINAINGYHGIEASLLALSKKKDLLLANKESLVIAGSQLEAIRKDTNTKIYPIDSEHSSLYDLLKDKKKNQIKQLIITASGAGQFNKNKEELIKLTYKDLLNHPNWNMGAEISINSATFINKVYEIVEAYHLFKVKDIIPVVERSSTIHAGVVYQDNSIHFHATTNDMRWAIQSALTKFDNKTNIVQALDIYQKSIQFEKIDFEQYPIFKIAYDILKNPYTTRGAVLTCINEYVVKLFQKQKINFLQITELISDFYWNYQHKKIDDIWQINDLIFKIKKAISSKYAYLDK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP059674
EMBL· GenBank· DDBJ
QMT98616.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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