A0A7D7FBF1 · A0A7D7FBF1_RHISN
- ProteinAngiotensin-converting enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids805 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
Catalytic activity
- angiotensin I + H2O = angiotensin-(1-9) + L-leucineThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 zinc ion per subunit.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 375 | Proton acceptor 1 | ||||
Sequence: E | ||||||
Active site | 505 | Proton donor 1 | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | extracellular space | |
Molecular Function | carboxypeptidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | metallopeptidase activity | |
Molecular Function | peptidyl-dipeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAngiotensin-converting enzyme
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Rhinolophoidea > Rhinolophidae > Rhinolophinae > Rhinolophus
Accessions
- Primary accessionA0A7D7FBF1
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 741-765 | Helical | ||||
Sequence: IWLIVFGVVMAVVVVGIVVLIITGI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MSGSSWLLLSLVAVTTA | ||||||
Chain | PRO_5027989671 | 18-805 | Angiotensin-converting enzyme | |||
Sequence: QSTTEDRAKMFLDTFNSEAEDLSYQSSLASWDYNTNINDENVQKMDEAGAKWSAFYEEQSKLAKNYSLEQIQNVTVKLQLQILQQSGSPVLSEDKSKRLNSILNAMSTIYSTGKVCKPNKPHECLLLEPGLDNIMGTSKDYNERLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEESPGPGYSRDQLMKDVERIFTEIKPLYEHLHAYVRAKLMDTYPFHISPTGCLPAHLLGDMWGRFWTNLYPLTVPFGQKPNIDVTDEMLKQGWDADRIFKEAEKFFVSVGLPNMTEGFWNNSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMEDFLTAHHEMGHIQYDMAYASQPYLLRNGANEGFHEAVGEVMSLSVATPKHLKTMGLLSPDFREDNETEINFLLKQALNIVGTLPFTYMLEKWRWMVFKGEIPKEEWMKKWWEMKRKIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRTIFEFQFHEALCRIAQHDGPLHKCDISNSTDAGKKLHQMLSVGKSKAWTETLKDIVDSRNMDVGPLLRYFEPLYTWLQEQNRKSYVGWNTDWSPYSDQSIKVRISLKSALGENAYEWNDNEMYLFRSSVAYAMREYFLKEKHQTILFGAENVWVSNLKPRISFNFHVTSPGNLSDIIPRPEVEGAIRMSRSRINDAFRLDDNSLEFLGIQPTLGPPYQPPVTIWLIVFGVVMAVVVVGIVVLIITGIRDRRKTDQARSEENPYSSVDLSKGENNPGFQNGDDVQTSF | ||||||
Glycosylation | 53 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 90 | N-linked (GlcNAc...) (complex) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 90 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 133↔141 | |||||
Sequence: CKPNKPHEC | ||||||
Glycosylation | 136 | N-linked (GlcNAc...) asparagine; partial | ||||
Sequence: N | ||||||
Glycosylation | 329 | N-linked (GlcNAc...) asparagine; partial | ||||
Sequence: N | ||||||
Disulfide bond | 344↔361 | |||||
Sequence: CHPTAWDLGKGDFRIKMC | ||||||
Disulfide bond | 530↔542 | |||||
Sequence: CRIAQHDGPLHKC | ||||||
Glycosylation | 578 | N-linked (GlcNAc...) asparagine; partial | ||||
Sequence: N |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 614-805 | Collectrin-like | ||||
Sequence: SDQSIKVRISLKSALGENAYEWNDNEMYLFRSSVAYAMREYFLKEKHQTILFGAENVWVSNLKPRISFNFHVTSPGNLSDIIPRPEVEGAIRMSRSRINDAFRLDDNSLEFLGIQPTLGPPYQPPVTIWLIVFGVVMAVVVVGIVVLIITGIRDRRKTDQARSEENPYSSVDLSKGENNPGFQNGDDVQTSF | ||||||
Region | 771-805 | Disordered | ||||
Sequence: TDQARSEENPYSSVDLSKGENNPGFQNGDDVQTSF | ||||||
Compositional bias | 777-805 | Polar residues | ||||
Sequence: EENPYSSVDLSKGENNPGFQNGDDVQTSF |
Sequence similarities
Belongs to the peptidase M2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length805
- Mass (Da)92,855
- Last updated2020-12-02 v1
- Checksum06945C2779D595F0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 777-805 | Polar residues | ||||
Sequence: EENPYSSVDLSKGENNPGFQNGDDVQTSF |