A0A7D6PD71 · A0A7D6PD71_ECHGR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COX1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • EgNq01
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Cestoda > Eucestoda > Cyclophyllidea > Taeniidae > Echinococcus > Echinococcus granulosus group

Accessions

  • Primary accession
    A0A7D6PD71

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-44Helical
Transmembrane65-86Helical
Transmembrane106-130Helical
Transmembrane151-173Helical
Transmembrane185-211Helical
Transmembrane243-262Helical
Transmembrane268-289Helical
Transmembrane301-326Helical
Transmembrane338-364Helical
Transmembrane371-396Helical
Transmembrane416-437Helical
Transmembrane449-474Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-484Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    536
  • Mass (Da)
    60,353
  • Last updated
    2020-12-02 v1
  • Checksum
    F4F83F514932E4FD
MSVVWLGSWVFTLDHKRIGVIYSLLGIWSGFVGLSFSLLIRVNFLEPYYNVIPLDCYNFLVTNHGIIMIFFFLMPILIGGFGNYLLPLLGGLSDLNLPRLNALSAWLLIPSLVFLLVSMCLGAGVGWTFYPPLSSSYFSSSCGVDFLMFSLHLAGVSSVFSSINFICTLYSVFMTNVFSRTSIVLWSYLFTSVLLLVTLPVLAAAITMLLFDRNFCSAFFDPLGGGDPILFQHMFWFFGHPEVYVLILPGFGIISHICLSISANFDAFGFYGLLFAMFSIVCLGSSVWGHHMFTVGLDVKTAVFFSSVTMIIGVPTGIKVFTWLYMLLNSSVNVSDPVLWWVVSFIVLFTFGGVTGIVLSACVLDNILHDTWFVVAHFHYVMSLGSYISIIVMFIWWWPLITGLSLNKCLLQCQCIISNVGFNLCFFPMHYFGLCGLPRRVRIYEYSYNWINVVCTVGSFISAFSGCFFVFILWESIVSKNEVLGSYNSSGLVDCLMSPVACHNDYFCYPYSVDYTYGVYYMRWVDDCTYAFVGWL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue536

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT800795
EMBL· GenBank· DDBJ
QLR06748.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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