A0A7D5Y6A2 · A0A7D5Y6A2_9ACTN
- ProteinGlycine dehydrogenase (decarboxylating)
- GenegcvP
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids938 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Catalytic activity
- glycine + H+ + N6-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] = CO2 + N6-[(R)-S8-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein]
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | glycine cleavage complex | |
Molecular Function | glycine binding | |
Molecular Function | glycine dehydrogenase (decarboxylating) activity | |
Molecular Function | pyridoxal phosphate binding | |
Biological Process | glycine decarboxylation via glycine cleavage system |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycine dehydrogenase (decarboxylating)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micromonosporales > Micromonosporaceae > Micromonospora
Accessions
- Primary accessionA0A7D5Y6A2
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 690 | N6-(pyridoxal phosphate)lysine | ||||
Sequence: K |
Interaction
Subunit
The glycine cleavage system is composed of four proteins: P, T, L and H.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-432 | Glycine cleavage system P-protein N-terminal | ||||
Sequence: RHIGPDGDDERRMLDVVGYGSIDELMDAAIPEVIRWHGALDLPEPASEHDALAQLRAIAGRNTVAVSMIGLGYYGTHTPAVIRRNVLENPAWYTAYTPYQPEISQGRLEALLNFQTMVTDLTGLATANASMLDEGTAAAEAMTLARRASKSRSSVYVVDADALPQTIAVITSRAQPLGIEVQVVDLDAQALPGEFFGLHLQYPGASGAVRDHAPLVAAAHAVGALVTVAADLLALTLLRAPGEIGADIAAGTTQRFGVPMGFGGPHAGYLAVRSGLERMLPGRLVGVSRDAAGDPAYRLALQTREQHIRREKATSNICTAQVLLAVMAGMYAVYHGPDGLRGIAARTHSMAARLAAGLRAGGVGVADVAFFDTVTAVVPGRAAQVVADAQRRGVNLRLVDADRVGISCDETTTGAHLAMVWAAF | ||||||
Domain | 758-879 | Glycine dehydrogenase C-terminal | ||||
Sequence: ATGVAVLAANYVAARLRGHFPVLYAGNKGLVAHECILDLRPVTRATGVSVDDVAKRLIDYGFHAPTMSFPVAGTLMVEPTESEDLAELDRFCDAMIAIRAEIDKVGSGQWPAGDNPLVNAPH |
Sequence similarities
Belongs to the GcvP family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length938
- Mass (Da)98,600
- Last updated2020-12-02 v1
- ChecksumEDE1A1D0318B531B