A0A7D5TL87 · A0A7D5TL87_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 5
  • Gene
    ND5
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number

Gene names

    • Name
      ND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A7D5TL87

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane84-105Helical
Transmembrane117-134Helical
Transmembrane140-160Helical
Transmembrane172-191Helical
Transmembrane272-294Helical
Transmembrane301-319Helical
Transmembrane325-347Helical
Transmembrane368-386Helical
Transmembrane406-424Helical
Transmembrane453-472Helical
Transmembrane484-507Helical
Transmembrane584-601Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_502848260522-602NADH-ubiquinone oxidoreductase chain 5

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain68-118NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Domain134-419NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Domain422-602NADH dehydrogenase subunit 5 C-terminal

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    602
  • Mass (Da)
    66,988
  • Last updated
    2020-12-02 v1
  • Checksum
    925CD753D087C256
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFXXVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALXHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLXLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYXTRMXLLTLTGQPXFPTLTNINENNXXXXXXXXRLAAGSLXAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLXALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQXXXSIITSTQKGMIKLYFLSFFFPLILTLLLI

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue602

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN687302
EMBL· GenBank· DDBJ
QLH92764.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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