A0A7D5PHH1 · A0A7D5PHH1_MERLU

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Bivalvia > Autobranchia > Heteroconchia > Euheterodonta > Imparidentia > Neoheterodontei > Venerida > Veneroidea > Veneridae > Meretrix

Accessions

  • Primary accession
    A0A7D5PHH1

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-44Helical
Transmembrane65-86Helical
Transmembrane106-128Helical
Transmembrane149-167Helical
Transmembrane194-220Helical
Transmembrane232-259Helical
Transmembrane279-301Helical
Transmembrane322-340Helical
Transmembrane352-374Helical
Transmembrane386-408Helical
Transmembrane428-449Helical
Transmembrane461-479Helical
Transmembrane499-522Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain49-563Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    579
  • Mass (Da)
    65,315
  • Last updated
    2020-12-02 v1
  • Checksum
    7516C58184E237EB
MKNLFGGSMFLESKIFKNVGSINNSFYGIFMDLGFEFVYFVYQVKKRCKTYIYRWFFSTNHKDIGTLYFIFSFWAGLVGTAFSVIIRMELSMPGTILDDAHLYNLIVTSHGLVMIFFLVMPMMLGGFGNWLVPLMLTAPDMAFPRLNNLSFWLLTSSLLLLLGSTYVEAGSGTGWTIYPPLSSWKYHSGVSVDYLILSLHVGGASSIMSGINFTTTAICMRPGVMALVRTPMFVWCIAVTGFLLVCAMPVLAAGLTMLLTDRNFNTGFFDPIGLGDPLLFVHMFWFFGHPEVYILILPAFGMISHVIKVGSGKRELFGKVPMIYAILSIGFLGFIVWGHHMFTVGMNVDSRAYFSTVTLIIAIPTGVKIFSWIATLYGGDVKNWVMLYWASGFIFLFTVGGLTGVILASASLDVVLHDTYYVVAHFHYVLSMGAVFGLFAGFHYWFPLFTGIGMHPVWSKAQFVSMLIGVNVTFFPQHFLGLSGMPRRYTDYIDSMHWFNFISSWGSMISLCSLFHFMFILFDAFLSQRGLVFWEVMNTESEWARKGFPTKFHNFSQNVWGFANTDIRKSAVKENNSKT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT418596
EMBL· GenBank· DDBJ
QLH90194.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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