A0A7D5JIJ9 · A0A7D5JIJ9_9CAUD
- ProteinNAD(+)--arginine ADP-ribosyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids694 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction.
Catalytic activity
- L-arginyl-[protein] + NAD+ = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H+
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 7-8 | Cleavage | |||
Active site | 589 | ||||
Site | 632-633 | Cleavage | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | virion component | |
Molecular Function | NAD+-protein-arginine ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | regulation of viral transcription |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(+)--arginine ADP-ribosyltransferase
- EC number
- Cleaved into 1 chains
Gene names
Organism names
- Organism
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Tevenvirinae > Dhakavirus
Accessions
- Primary accessionA0A7D5JIJ9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_5042302455 | 1-694 | NAD+--arginine ADP-ribosyltransferase | ||
Post-translational modification
Proteolytic cleavages at the N- and C-termini by the prohead core protein protease give rise to the mature enzyme.
Structure
Sequence
- Sequence statusComplete
- Length694
- Mass (Da)77,282
- Last updated2020-12-02 v1
- MD5 Checksum8A3B767E97832E7DD9D41395BB406D18
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MT682711 EMBL· GenBank· DDBJ | QLF81296.1 EMBL· GenBank· DDBJ | Genomic DNA |