A0A7D5FQ68 · A0A7D5FQ68_9CAUD

Function

function

ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for site, active site.

169750100150200250300350400450500550600650
Type
IDPosition(s)Description
Site6-7Cleavage
Active site589
Site632-633Cleavage

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentvirion component
Molecular FunctionNAD+-protein-arginine ADP-ribosyltransferase activity
Molecular Functionnucleotidyltransferase activity
Biological Processregulation of viral transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • ORF names
      FT_0082

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Tevenvirinae > Tequatrovirus

Accessions

  • Primary accession
    A0A7D5FQ68

Proteomes

Subcellular Location

Virion
Note: About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA.

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50423026901-697NAD+--arginine ADP-ribosyltransferase

Post-translational modification

Proteolytic cleavages at the N- and C-termini by the prohead core protein protease give rise to the mature enzyme.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain378-627ADP ribosyltransferase

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    697
  • Mass (Da)
    77,941
  • Last updated
    2020-12-02 v1
  • MD5 Checksum
    4CA536A51CA8B02CD94053420270471B
MELITELFDEDTTLPITNLNPKKKIPQIFSVHVDDAIEQPGFRLCTYTSGGDTNRDLKMGDKMMHIVPFTLTAKGSIAKLKGLGPSPINYINSVFTVAMQTMRQYKIDACMLRILKSKTAGQARQIQVIADRLIRSRSGGRYVLLKELWDYDKKYAYILIHRKNVSLENIPGVPEISTELFTKVESKVGDVYINKDTGAQVTKNEAIAASIAQENDKRSDQAVIVKVKISRRAIAQSQSLESSRFESELFQKYESTAANFNKPATAPLIPEAEEMKIGINSLASKTKAAKIIAEGTADELHYDYKFFPMSQVGEVSEKIKEVIFNAIKNEPTTSIKCLEKYAAAVNQFFEDYKDKWLANHNKNRKGQPDEVWEEITKNSWNAAKTKFLKRMIYSFSGIGAGPMIDITITRDGSKYTPSQKRGIREYCGSGYTDINNLLLGRYNPERYDVMSEKEIESAINNLDSAFENGDRIPEGITVYRAQSMTAPIYEALVKNKVFYFRNFVSTSLTPIIFGRFGITHAGIGLLEPEARNELTVDKNEEGITINPNEIRAYKENPEYVKVQIGWAIDGAHKVNVVYPGSLGIATEAEVILPRGLMVKVNKITDASNNDGTTSNNTKLIQAEVMTTEELTESVIYDGDHLMETGELVAMTGDIEIEDRVDFASFVSSNVKQKVESSLGIIASCIDITNMPYKFVQG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT682710
EMBL· GenBank· DDBJ
QLF81030.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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