A0A7D4X8B8 · A0A7D4X8B8_9ALPC
- ProteinPolyprotein 1a
- GeneORF1a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids4117 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell membrane | |
Cellular Component | host cell perinuclear region of cytoplasm | |
Cellular Component | membrane | |
Molecular Function | cysteine-type deubiquitinase activity | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | omega peptidase activity | |
Molecular Function | RNA binding | |
Molecular Function | transferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | induction by virus of host autophagy | |
Biological Process | proteolysis | |
Biological Process | symbiont-mediated perturbation of host ubiquitin-like protein modification | |
Biological Process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity | |
Biological Process | viral genome replication | |
Biological Process | viral protein processing | |
Biological Process | viral translational frameshifting | |
Biological Process | virus-mediated perturbation of host defense response |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Alphacoronavirus > Pedacovirus
Accessions
- Primary accessionA0A7D4X8B8
Subcellular Location
UniProt Annotation
GO Annotation
Host membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1964-1982 | Helical | ||||
Sequence: LITVFFYVLSILGLCFRAF | ||||||
Transmembrane | 2025-2044 | Helical | ||||
Sequence: VLGKFSLGIYALYALLFMTI | ||||||
Transmembrane | 2104-2125 | Helical | ||||
Sequence: LIGNVMPFFYLAFLAIFGGVYV | ||||||
Transmembrane | 2132-2153 | Helical | ||||
Sequence: FICQYLNILGVFLGLQQSIWFL | ||||||
Transmembrane | 2165-2185 | Helical | ||||
Sequence: IVVFFIVTRVLMFLKHVFLGC | ||||||
Transmembrane | 2528-2546 | Helical | ||||
Sequence: FFWSLCLFIVAVFFALSFL | ||||||
Transmembrane | 2787-2804 | Helical | ||||
Sequence: ILFNCIIAFAAVAVCLLF | ||||||
Transmembrane | 2816-2839 | Helical | ||||
Sequence: VGVFTVGACTLLNNVSYIVTQNTL | ||||||
Transmembrane | 2859-2887 | Helical | ||||
Sequence: WIWHLGFLISYILIAPWWVLMVYAFSAIF | ||||||
Transmembrane | 3337-3354 | Helical | ||||
Sequence: YVTPMFACLSLLSSLLMF | ||||||
Transmembrane | 3361-3381 | Helical | ||||
Sequence: LFFQVFLIPALIVTSCINLAF | ||||||
Transmembrane | 3401-3419 | Helical | ||||
Sequence: GFNAQGLVNIFVCFVVTIL | ||||||
Transmembrane | 3431-3449 | Helical | ||||
Sequence: PVSSVTYVVALLTAAYNYF | ||||||
Transmembrane | 3469-3493 | Helical | ||||
Sequence: WFVGAVCYKAAVYMALRFPTFVAIF | ||||||
Transmembrane | 3500-3520 | Helical | ||||
Sequence: MFCYLVLGYFTCCFYGILYWF |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 2-109 | CoV Nsp1 globular | ||||
Sequence: ASNHVTLAFANDAEISAFGFCTASEAVSYYSEAAASGFMQCRFVSFDLADTVEGLLPEDYVMVVVGTTKLSAYVDTFGSRPKNICGWLLFSNCNYFLEELELTFGRCG | ||||||
Domain | 112-364 | CoV Nsp2 N-terminal | ||||
Sequence: IVPVDQYMCGADGKPVLQESEWEYTDFFADSEDGQLNIAGITYVKAWIVERSDVSYASQNLTSIKSITYCSTYEHTFPDGTAMKVARTPKIKKTVVLSEPLATIYREIGSPFVDNGSDARSIIKRPVFLHAFVKCKCGSYHWTVGDWTSYVSTCCGFKCKPVLVASCSATPGSVVVTRAGAGTGVKYYNNMFLRHVADIDGLAFWRILKVQSKDDLACSGKFLEHHEEGFTDTCYFLNDSSIATKLKFDILSG | ||||||
Domain | 383-776 | CoV Nsp2 middle | ||||
Sequence: SALVDIVDDALGQPWFIRKLGDLVSAAWEQLKAVVRGLNLLSDEVVLFGKRLSCATLSIVNGVFEFLAEVPEKLAAAVTVFVNFLNEFFESACDCLKVGGKTFNKVGSYVLFDNALVKLVKAKVRGPRQAGVCEVRYTSLVIGSTTKVVSKRVENANVNLVVVDEDVTLNTTGRTVVVDGLAFFESDGFYRHLADADVVIEHPVYKSACELKPVFECDPIPDFPMPVAASVAELCVQTDLLLKNYNTPYKTYSCVVRGDKCCITCTLHFTAPSYMEAAANFVDLCTKNIGTAGFHEFYITAHEQQDLQGFVTTCCTMSGFECFMPIIPQCPAVLEEIDGGSIWRSFITGLNTMWDFCKHLKVSFGLDGIVVTVARKFKRLGALLAEMYNTYLST | ||||||
Domain | 778-895 | CoV Nsp2 C-terminal | ||||
Sequence: VENLVLAGVSFKYYATSVPKIVLGCCFHSVKSVLASAFQIPVQAGVEKFKVFLNCVHPVVPRVIETSFVELEETTFKPPALNGSIAIVDGFAFYYDGTLYYPTDGNSVVPICFKKKGG | ||||||
Domain | 896-991 | Ubiquitin-like | ||||
Sequence: GDVKFSDEVSVKTIDPVYKVSLEFEFESETIMAVLNKAVGNCIKVTGGWDDVVEYINVAIEVLKDHIDVPKYYIYDEEGGTDPNLPVMVSQWPLND | ||||||
Region | 1012-1040 | Disordered | ||||
Sequence: EGDEVDSSEPDKVADVANSEPEDDGLNVA | ||||||
Domain | 1057-1296 | Peptidase C16 | ||||
Sequence: SFIKDTPSTVTKDPFAFDFASYGGLKVLRQSHNNCWVTSTLVQLQLLGIVDDPAMELFSAGRVGPMVRKCYESQKAILGSLGDVSACLESLTKDLHTLKITCSVVCGCGTGERIYEGCAFRMTPTLEPFPYGACAQCAQVLMHTFKSIVGTGIFCRDPTALSLDSLVVKPFCAAAFIGKDSGHYVTNFYDAAMAIDGYGRHQIKYDTLNTICVKDVNWTAPFVPDVEPVLEPVVKPFYSY | ||||||
Domain | 1286-1465 | Macro | ||||
Sequence: LEPVVKPFYSYKNVDFYQGDFSDLVKLPCDFVVNAANENLSHGGGIAKAIDVYTKGMLQKCSNDYIKAHGPIKVGRGVMLEALGLKVFNVVGPRKGKHAPELLVKAYKSVFANSGVALTPLISVGIFSVPLEESLSAFLACVGDRHCKCFCYSDKEREAIINYMDGLVDAIFKDALVDTT | ||||||
Domain | 1630-1685 | Ubiquitin-like | ||||
Sequence: NKSVVIKVTEDTRSVKAVKVESTVTYGQQIGPCLVNDTVVTDNKPVVADVVAKVVP | ||||||
Domain | 1691-1951 | Peptidase C16 | ||||
Sequence: SHYGFDKAGEFHMLDHTGFAFPSEVVNGRRVLKTTDNNCWVNVTCLQLQFARFRFKSAGLQAMWESYCTGDVAMFVHWLYWLTGVDKGQPSDSENALNMLSKYIVSAGSVTIERVTHDGCCCSKRVVTAPVVNASVLKLGVEDGLCPHGLNYIDKVVVVKGTTIVVNVGKPVVAPSHLFLKGVSYTTFLDNGNGVVGHYTVFDHDTGMVHDGDAFVPGDLNVSPVTNVVISEQTAVVIKDPVKKVELDATKLLDTMNYASE | ||||||
Domain | 2038-2102 | 3Ecto | ||||
Sequence: ALLFMTIRFTPIGGPVCDDVVAGYANSSFDKNEYCNSVICKVCLYGYQELSDFSHTQVVWQHLRD | ||||||
Region | 2176-2266 | Y1 | ||||
Sequence: MFLKHVFLGCDKASCVACSRSARLKRVPVQTIFQGTSKSFYVHANGGSKFCKKHNFFCLNCDSYGPGCTFINDVIATEVGNVVKLNVQPTG | ||||||
Domain | 2176-2516 | CoV Nsp3 Y | ||||
Sequence: MFLKHVFLGCDKASCVACSRSARLKRVPVQTIFQGTSKSFYVHANGGSKFCKKHNFFCLNCDSYGPGCTFINDVIATEVGNVVKLNVQPTGPATILIDKVEFSNGFYYLYSGDTFWKYNFDITDSKYTCKESLKNCSIITDFIVFNNNGSNVNQVKNACVYFSQMLCKPVKLVDSALLASLSVDFGASLHSAFVSVLSNSFGKDLSSCNDMQDCKSTLGFDDVPLDTFNAAVAEAHRYDVLLTDMSFNNFTTSYAKPEEKLPVHDIATCMRVGAKIVNHNVLVKDSIPVVWLVRDFIALSEETRKYIIRTTKVKGITFMLTFNDCRMHTTIPTVCIANKKG | ||||||
Region | 2180-2193 | ZF1 | ||||
Sequence: HVFLGCDKASCVAC | ||||||
Region | 2226-2236 | ZF2 | ||||
Sequence: CKKHNFFCLNC | ||||||
Region | 2267-2516 | CoV-Y | ||||
Sequence: PATILIDKVEFSNGFYYLYSGDTFWKYNFDITDSKYTCKESLKNCSIITDFIVFNNNGSNVNQVKNACVYFSQMLCKPVKLVDSALLASLSVDFGASLHSAFVSVLSNSFGKDLSSCNDMQDCKSTLGFDDVPLDTFNAAVAEAHRYDVLLTDMSFNNFTTSYAKPEEKLPVHDIATCMRVGAKIVNHNVLVKDSIPVVWLVRDFIALSEETRKYIIRTTKVKGITFMLTFNDCRMHTTIPTVCIANKKG | ||||||
Region | 2415-2516 | Y4 | ||||
Sequence: VLLTDMSFNNFTTSYAKPEEKLPVHDIATCMRVGAKIVNHNVLVKDSIPVVWLVRDFIALSEETRKYIIRTTKVKGITFMLTFNDCRMHTTIPTVCIANKKG | ||||||
Domain | 2902-2997 | Nsp4C | ||||
Sequence: LFEGDKFVGSFENAAAGTFVLDMHAYERLANSISTEKLRQYASTYNKYKYYSGSASEADYRLACFAHLAKAMMDYASNHNDTLYTPPTVSYNSTLQ | ||||||
Domain | 2998-3299 | Peptidase C30 | ||||
Sequence: AGLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDTVMCPRHVIASSTTSTIDYDYALSVLRLHNFSISSGNVFLGVVGVTMRGALLQIKVNQNNVHTPKYTYRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGYNINNGTVEFCYLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTENVLAFLYAALINGSTWWLSSSRIAVDRFNEWAVHNGMTTVGNTDCFSILAAKTGVDVQRLLASIQSLHKNFGGKQILGYTSLTDEFTTGEVIRQMYGVNLQ | ||||||
Domain | 3580-3662 | RdRp Nsp7 cofactor | ||||
Sequence: SKLTDIKCSNVVLLGCLSSMNVSANSTEWAYCVDLHNKINLCNDPEKAQEMLLALLAFFLSKNSAFGLDDLLESYFNDNSMLQ | ||||||
Domain | 3663-3857 | RdRp Nsp8 cofactor | ||||
Sequence: SVASTYVGLPSYVIYENARQQYEDAVNNGSPPQLVKQLRHAMNVAKSEFDREASTQRKLDRMAEQAAAQMYKEARAVNRKSKVVSAMHSLLFGMLRRLDMSSVDTILNLAKDGVVPLSVIPAVSATKLNIVTSDIDSYNRIQREGCVHYAGTIWNIIDIKDNDGKVVHVKEVTAQNAESLSWPLVLGCERIVKLQ | ||||||
Domain | 3858-3965 | Nsp9 ssRNA-binding | ||||
Sequence: NNEIIPGKLKQRSIKAEGDGIVGEGKALYNNEGGRTFMYAFISDKPDLRVVKWEFDGGCNTIELEPPRKFLVDSPNGAQIKYLYFVRNLNTLRRGAVLGYIGATVRLQ | ||||||
Domain | 3966-4103 | ExoN/MTase coactivator | ||||
Sequence: AGKQTEQAINSSLLTLCAFAVDPAKTYIDAVKSGHKPVGNCVKMLANGSGNGQAVTNGVEASTNQDSYGGASVCLYCRAHVEHPSMDGFCRLKGKYVQVPLGTVDPIRFVLENDVCKVCGCWLANGCTCDRSIMQSTD |
Sequence similarities
Belongs to the coronaviruses polyprotein 1ab family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length4,117
- Mass (Da)452,855
- Last updated2020-12-02 v1
- Checksum13BFBF4387B71A0A
Keywords
- Coding sequence diversity