A0A7D4WTF8 · A0A7D4WTF8_9ALPC

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
    EC:3.4.19.12 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionomega peptidase activity
Molecular FunctionRNA binding
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processinduction by virus of host autophagy
Biological Processproteolysis
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Biological Processviral genome replication
Biological Processviral protein processing
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Polyprotein 1a

Gene names

    • Name
      ORF1a

Organism names

  • Taxonomic identifier
  • Strain
    • PEDV-2118-1-Orense-Covelas
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Alphacoronavirus > Pedacovirus

Accessions

  • Primary accession
    A0A7D4WTF8

Subcellular Location

Host membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1964-1982Helical
Transmembrane2025-2044Helical
Transmembrane2104-2125Helical
Transmembrane2132-2153Helical
Transmembrane2165-2185Helical
Transmembrane2528-2546Helical
Transmembrane2787-2804Helical
Transmembrane2859-2887Helical
Transmembrane3337-3354Helical
Transmembrane3361-3381Helical
Transmembrane3401-3419Helical
Transmembrane3431-3449Helical
Transmembrane3469-3493Helical
Transmembrane3500-3520Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain2-109CoV Nsp1 globular
Domain112-364CoV Nsp2 N-terminal
Domain383-776CoV Nsp2 middle
Domain778-895CoV Nsp2 C-terminal
Domain896-991Ubiquitin-like
Region1012-1039Disordered
Domain1057-1296Peptidase C16
Domain1286-1465Macro
Domain1630-1685Ubiquitin-like
Domain1691-1951Peptidase C16
Domain2038-21023Ecto
Region2176-2266Y1
Domain2176-2516CoV Nsp3 Y
Region2180-2193ZF1
Region2226-2236ZF2
Region2267-2516CoV-Y
Region2415-2516Y4
Domain2902-2997Nsp4C
Domain2998-3299Peptidase C30
Domain3580-3662RdRp Nsp7 cofactor
Domain3663-3857RdRp Nsp8 cofactor
Domain3858-3965Nsp9 ssRNA-binding
Domain3966-4103ExoN/MTase coactivator

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    4,117
  • Mass (Da)
    453,053
  • Last updated
    2020-12-02 v1
  • Checksum
    12D3BC4AE1DFDE21

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MN692788
EMBL· GenBank· DDBJ
QKV43822.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp